从青霉菌中提取的具有生物活性和不寻常的甾体。
Bioactive and unusual steroids from Penicillium fungi.
机构信息
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA.
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA.
出版信息
Phytochemistry. 2023 May;209:113638. doi: 10.1016/j.phytochem.2023.113638. Epub 2023 Mar 11.
Penicillium fungi are represented by various species and can be found worldwide and thrive in a range of environments, such as in the soil, air, and indoors, and in marine environments, as well as food products. Chemical investigation of species of this genus has led to the discovery of compounds from several structural classes with varied bioactivities. As an example, this genus has been a source of bioactive and structurally unusual steroids. The scope of this short review is to cover specialized metabolites of the steroid class and the cytotoxic, antimicrobial, anti-inflammatory as well as phytotoxic activities of these compounds. Other steroids that possess unusual structures, with significant bioactivity yet to determined, will also be discussed to further demonstrate the structural diversity of this compound class from Penicillium fungi, and hopefully inspire the further exploration of such compounds to uncover their activity.
青霉属真菌由各种不同的物种组成，在世界各地都有分布，并能在多种环境中生长，例如土壤、空气和室内，以及海洋环境和食品中。对该属物种的化学研究导致发现了具有多种生物活性的化合物，这些化合物来自几个不同结构类型。例如，该属是具有生物活性和结构不寻常的甾体化合物的来源。本文综述的范围将涵盖甾体类的特殊代谢产物，以及这些化合物的细胞毒性、抗菌、抗炎和植物毒性活性。其他具有不寻常结构的甾体化合物，尽管具有显著的生物活性，但尚未确定，也将进行讨论，以进一步展示青霉属真菌中这类化合物的结构多样性，并希望激发对这些化合物的进一步探索，以揭示其活性。
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