Fodor J, Meyer K, Riedlberger M, Bauer J, Horn P, Kovacs F, Kovacs M
Research Group of Animal Breeding and Animal Hygiene, University of Kaposvár, Faculty of Animal Science [corrected] Guba S. 40., Kaposvár, H-7400, Hungary.
Food Addit Contam. 2006 May;23(5):492-501. doi: 10.1080/02652030500544964.
The distribution and elimination of fumonisins after oral administration of 50 mg FB(1), 20 mg FB(2) and 5 mg FB(3) per animal day(-1) for 22 days was studied in weaned barrows. At the end of the trial, the lung, heart, liver, kidney, spleen, brain, serum, bile, muscle, fat, urine and faeces samples were collected and their content of fumonisins (FB(1), FB(2)) determined by LC-MS. The highest FB(1) concentrations were found in the liver (99.4 +/- 37.5 ng g(-1)) and kidneys (30.6 +/- 10.1 ng g(-1)), whilst the highest average amount of FB(2) was in the liver (1.4 +/- 2.3 ng g(-1)) and fat (2.6 ng g(-1) +/- 4.8) samples. Comparing the FB(1)/FB(2) ratio in different organs (19/1), it was found that the ratio in the abdominal and subcutaneous fat samples (4/1) was markedly different from those in all other tissues, namely the relative proportion of FB(2) was higher in latter cases. Of the total quantity of FB(1), the 13% taken up during 5 days was excreted unchanged with the faeces and urine. On average, in the urine and faeces, FB(1) was detected in nine- and 14-fold quantities, as compared with FB(2).
在断奶仔猪中研究了每天每只动物口服50毫克伏马毒素B1（FB1）、20毫克伏马毒素B2（FB2）和5毫克伏马毒素B3（FB3），持续22天之后伏马毒素的分布和消除情况。试验结束时，收集了肺、心脏、肝脏、肾脏、脾脏、大脑、血清、胆汁、肌肉、脂肪、尿液和粪便样本，并通过液相色谱 - 质谱法测定其中伏马毒素（FB1、FB2）的含量。发现肝脏（99.4±37.5纳克/克）和肾脏（30.6±10.1纳克/克）中的FB1浓度最高，而肝脏（1.4±2.3纳克/克）和脂肪（2.6纳克/克±4.8）样本中的FB2平均含量最高。比较不同器官中的FB1/FB2比率（19/1），发现腹部和皮下脂肪样本中的比率（4/1）与所有其他组织中的比率明显不同，即在其他情况下FB2的相对比例更高。在FB1的总量中，5天内摄取的13%以不变的形式随粪便和尿液排出。平均而言，在尿液和粪便中，检测到的FB1含量分别是FB2的9倍和14倍。
