Reynolds Kim D, Spruijt-Metz Donna
University of Southern California, Institute for Health Promotion and Disease Prevention Research, Alhambra, CA 91803, USA.
Eval Health Prof. 2006 Jun;29(2):219-45. doi: 10.1177/0163278706287346.
This article explores the state of translational research in childhood obesity prevention. Five phases of translational research and emerging findings from basic science that could be useful in the design of obesity prevention programs are described. Few intervention studies have been published, and these are dominated by Phase 3 trials (efficacy), conducted in school settings, with a limited number of studies finding significant effects on Body Mass Index or adiposity. Cost-benefit analyses are lacking. Research is needed to translate basic science findings into novel interventions (Phases 1 and 2) and to translate programs with known behavior change capability into dissemination trials (Phase 5). Translation can be facilitated by enhanced communication between basic science and prevention science researchers, the development of interventions for underused settings, using novel strategies, support by institutions and funding agencies for translation, and the design of interventions with translation in mind.
本文探讨了儿童肥胖预防领域的转化研究现状。文中描述了转化研究的五个阶段以及基础科学领域的新发现，这些发现可能有助于肥胖预防项目的设计。已发表的干预研究较少，且主要是在学校环境中进行的3期试验（疗效试验），仅有少数研究发现对体重指数或肥胖有显著影响。目前缺乏成本效益分析。需要开展研究，将基础科学研究成果转化为新的干预措施（1期和2期），并将具有已知行为改变能力的项目转化为推广试验（5期）。加强基础科学研究人员与预防科学研究人员之间的沟通、针对未充分利用的环境开发干预措施、采用新策略、机构和资助机构对转化研究的支持以及在设计干预措施时考虑到转化等，都有助于推动转化研究。
