通过期望最大化（EM）算法对DNA序列进化模型进行统计推断。
Statistical inference in evolutionary models of DNA sequences via the EM algorithm.
作者信息
Hobolth Asger, Jensen Jens Ledet
机构信息
Bioinformatics Research Center, University of Aarhus, Denmark.
出版信息
Stat Appl Genet Mol Biol. 2005;4:Article18. doi: 10.2202/1544-6115.1127. Epub 2005 Aug 12.
PMID:16646835
Abstract
We describe statistical inference in continuous time Markov processes of DNA sequences related by a phylogenetic tree. The maximum likelihood estimator can be found by the expectation maximization (EM) algorithm and an expression for the information matrix is also derived. We provide explicit analytical solutions for the EM algorithm and information matrix.
摘要
我们描述了由系统发育树相关的DNA序列连续时间马尔可夫过程中的统计推断。最大似然估计量可通过期望最大化（EM）算法找到，并且还推导了信息矩阵的表达式。我们为EM算法和信息矩阵提供了明确的解析解。
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