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[普萘洛尔对艾氏腹水瘤细胞培养中G2期抑素和肾上腺素的有丝分裂抑制活性的影响]

[Effects of propranolol on mitosis-inhibiting activity of G2-chalone and adrenaline in cell culture of Ehrlich's ascites tumor].

作者信息

Antokhin A I, Popova N Ia, Gembitskiĭ D S, Romanov Iu A

出版信息

Biull Eksp Biol Med. 1991 Jul;112(7):98-9.

PMID:1665361
Abstract

Chalone-containing preparation from ascite Ehrlich's tumour blocks these cell transition from G2-phase to mitosis and its motion in mitosis in vitro (G2-block, M-block). Adrenaline blocks these cell transition from G2-phase to mitosis. Propranolol raises G2-block of chalone or adrenaline. Consequently this way of chalones action on cell division includes beta-adrenergic receptors influence of preparation on cell motion in mitosis doesn't change with addition of propranolol. Consequently this way of chalone system action on mitosis doesn't include beta-adrenergic receptors.

摘要

来自艾氏腹水瘤的含抑素制剂可阻止这些细胞从G2期过渡到有丝分裂,并阻止其在体外有丝分裂中的运动(G2期阻滞、M期阻滞)。肾上腺素可阻止这些细胞从G2期过渡到有丝分裂。普萘洛尔可增强抑素或肾上腺素的G2期阻滞作用。因此,抑素对细胞分裂的作用方式包括β-肾上腺素能受体的影响,制剂对有丝分裂中细胞运动的影响不会因加入普萘洛尔而改变。因此,抑素系统对有丝分裂的作用方式不包括β-肾上腺素能受体。

相似文献

1
[Effects of propranolol on mitosis-inhibiting activity of G2-chalone and adrenaline in cell culture of Ehrlich's ascites tumor].[普萘洛尔对艾氏腹水瘤细胞培养中G2期抑素和肾上腺素的有丝分裂抑制活性的影响]
Biull Eksp Biol Med. 1991 Jul;112(7):98-9.
2
[Effect of adrenaline on the mitosis-inhibiting action of a chalone-containing preparation in Ehrlich ascites tumor].[肾上腺素对含抑素制剂在艾氏腹水瘤中抑制有丝分裂作用的影响]
Biull Eksp Biol Med. 1988 Mar;105(3):345-7.
3
[Effect of different fractions obtained by gel filtration of a chalone-containing preparation from Ehrlich ascites tumor on mitotic activity and DNA synthesis in this tumor].[从艾氏腹水瘤含查隆的制剂经凝胶过滤得到的不同级分对该肿瘤有丝分裂活性和DNA合成的影响]
Biull Eksp Biol Med. 1988 Aug;106(8):202-4.
4
[Effect of a chalone-containing preparation from Ehrlich ascites tumor on DNA synthesis and cell division in the tumor in relation to the time of day].
Tsitologiia. 1982 Nov;24(11):1312-8.
5
[Combined effect of epinephrine and chalone extracted from Ehrlich ascites carcinoma administered during different time of day on cell division in the tumor].[不同时间给予肾上腺素与艾氏腹水癌提取的抑素对肿瘤细胞分裂的联合作用]
Biull Eksp Biol Med. 1982 Oct;94(10):100-2.
6
[Fractionation of a chalone-containing substance from Ehrlich's ascites tumor using high pressure chromatography].[使用高压色谱法从艾氏腹水瘤中分离含查耳酮的物质]
Biull Eksp Biol Med. 1991 Oct;112(10):418-9.
7
[Cell division and changes of the duration of mitosis in murine Ehrlich ascites carcinoma after a single administration of chalone-containing extract from this tumor].[单次给予含抑素的小鼠艾氏腹水癌提取物后该肿瘤的细胞分裂及有丝分裂持续时间的变化]
Biull Eksp Biol Med. 1982 Mar;93(3):81-3.
8
[Relation between the mitosis-inhibitory activity of a chalone preparation of Ehrlich ascites tumor and its diurnal secretion].[艾氏腹水瘤查隆制剂的有丝分裂抑制活性与其昼夜分泌之间的关系]
Biull Eksp Biol Med. 1981 Mar;91(3):343-5.
9
[Action of the chalone from Ehrlich's ascites, tumor in mice on the mitotic activity in this tumor after single and double administrations].[艾氏腹水瘤抑素对小鼠该肿瘤单次及两次给药后有丝分裂活性的作用]
Biull Eksp Biol Med. 1980 Feb;89(2):189-91.
10
[Effect of different doses of a chalone-containing alcohol precipitate of Ehrlich ascitic tumor on the mitotic activity and DNA synthesis in this tumor].[不同剂量艾氏腹水瘤含抑素乙醇沉淀物对该肿瘤有丝分裂活性及DNA合成的影响]
Biull Eksp Biol Med. 1987 Jan;103(1):89-92.