[使用高压色谱法从艾氏腹水瘤中分离含查耳酮的物质]
[Fractionation of a chalone-containing substance from Ehrlich's ascites tumor using high pressure chromatography].
作者信息
Popova N Ia, Antokhin A I, Adrianov N V, Tret'iakova L Z, Romanov Iu A
出版信息
Biull Eksp Biol Med. 1991 Oct;112(10):418-9.
PMID:1839508
Abstract
The effect of various fractions of chalone--containing preparation from ascyte Ehrlich's tumour obtained by high performance liquid chromatography (HPLC) on mitotic activity and DNA synthesis in the tumour has been studied. After filtration the division of active chalone component which inhibits entering cells into M-phase and S-phase took place. The component inhibiting DNA synthesis eluated with G1-chalone.
摘要
研究了通过高效液相色谱法（HPLC）从艾氏腹水瘤细胞中获得的含查隆的制剂的不同组分对肿瘤有丝分裂活性和DNA合成的影响。过滤后，发生了抑制细胞进入M期和S期的活性查隆成分的分离。抑制DNA合成的成分与G1-查隆一起洗脱出来。
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