Breitschwerdt E B, Davidson M G, Aucoin D P, Levy M G, Szabados N S, Hegarty B C, Kuehne A L, James R L
Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Antimicrob Agents Chemother. 1991 Nov;35(11):2375-81. doi: 10.1128/AAC.35.11.2375.
Dogs were experimentally inoculated with Rickettsia rickettsii to characterize the comparative efficacies of chloramphenicol, enrofloxacin, and tetracycline for the treatment of Rocky Mountain spotted fever (RMSF). All three antibiotics were equally effective in abrogating the clinical, hematologic, and vascular indicators of rickettsial infection. Antibiotic treatment for 24 h was sufficient to decrease the rickettsemia to levels below detection by Vero cell culture. Early treatment with all three antibiotics resulted in a similar decrease in antibody titer, but acute and convalescent serum samples taken at appropriate times would have still facilitated an accurate diagnosis of RMSF in all but one dog, which did not seroconvert. We conclude that chloramphenicol, enrofloxacin, and tetracycline are equally efficacious for treating experimental canine RMSF.
通过实验给犬接种立氏立克次体，以表征氯霉素、恩诺沙星和四环素治疗落基山斑疹热（RMSF）的相对疗效。所有三种抗生素在消除立克次体感染的临床、血液学和血管指标方面同样有效。抗生素治疗24小时足以将立克次体血症降低至通过Vero细胞培养检测不到的水平。所有三种抗生素的早期治疗导致抗体滴度有相似程度的下降，但在适当时间采集的急性期和恢复期血清样本，除一只未发生血清转化的犬外，仍有助于对所有犬准确诊断RMSF。我们得出结论，氯霉素、恩诺沙星和四环素在治疗实验性犬RMSF方面同样有效。
