Pribytkov Iu N, Korshunov N I, Frizen B N
Ter Arkh. 1991;63(5):86-90.
Radioimmunoassay was used to study the content of prostaglandins in blood plasma of patients suffering from rheumatoid arthritis (PGE in 133 and PGF2 alpha in 102 patients). It has been established that as compared to the control group subjects, it is appreciably elevated and reflects the degree of inflammatory process activity, being pronounced to a greater measure in persons not receiving glucocorticoids than in hormone-dependent patients. A relationship has been revealed between the content of PGE and PGF2 alpha and certain clinical and laboratory characteristics (disease standing, intensity of exudative component of inflammation, the presence of humoral and cellular immunity disorders, anemia, and some visceral lesions), which may be of definite importance in the assessment of the patient's status. The time-course of changes in blood plasma prostaglandins reflects on the whole the dynamics of the disease activity, being related to a greater degree to the application of nonsteroidal antiinflammatory agents than of glucocorticoids.
采用放射免疫分析法研究类风湿性关节炎患者血浆中前列腺素的含量（133例患者检测PGE，102例患者检测PGF2α）。结果发现，与对照组受试者相比，患者血浆中前列腺素含量明显升高，反映了炎症过程的活动程度，且在未接受糖皮质激素治疗的患者中比在激素依赖型患者中更为明显。研究还揭示了PGE和PGF2α的含量与某些临床和实验室特征（疾病状况、炎症渗出成分的强度、体液和细胞免疫紊乱的存在、贫血以及一些内脏病变）之间的关系，这对于评估患者的病情可能具有一定的重要意义。血浆前列腺素变化的时间进程总体上反映了疾病活动的动态变化，与非甾体抗炎药的应用关系更大，而与糖皮质激素的应用关系较小。
