Holdsworth G, Coleman R
Biochim Biophys Acta. 1975 Apr 21;389(1):47-50. doi: 10.1016/0005-2736(75)90384-3.
The activities of subcellular marker enzymes in bile and liver homogenate from several mammalian species have provided information on the specificity of protein release during bile formation. The presence of significant amounts of the plasma membrane enzymes alkaline phosphodiesterase I and leucyl-beta-naphthylamidase in bile, in addition to alkaline phosphatase and 5'-nucleotidase, and the relative absence of intracellular enzymes lends support to the view that bile salt liberation from the hepatocyte is accompanied by a partial solubilization of the plasma (canalicular) membrane without extensive damage to the whole hepatocyte.
几种哺乳动物胆汁和肝脏匀浆中亚细胞标记酶的活性，为胆汁形成过程中蛋白质释放的特异性提供了信息。除碱性磷酸酶和5'-核苷酸酶外，胆汁中还存在大量质膜酶碱性磷酸二酯酶I和亮氨酰-β-萘酰胺酶，而细胞内酶相对缺乏，这支持了以下观点：肝细胞释放胆汁盐的同时，质膜（胆小管）会部分溶解，但整个肝细胞不会受到广泛损伤。
