Zhao Y
Zhonghua Yi Xue Za Zhi. 1991 Nov;71(11):612-5, 42.
Aortic thrombosis in de-endotheliazed rabbit and 51Cr labeled autologous platelets were used for the evaluation of in vivo effects of CsB-851 on platelet-vessel wall interaction. The result showed that when CsB-851, an active part of alcoholic extract of mycelium from Cordyceps sinensis (Berk.) Sacc., was infused intravenously, the 51Cr labeled platelet number per gram dry weight of injured abdominal aorta (98.14 +/- 9.41 x 10(6)) was much lower than that in the control group (201.25 +/- 27.21 x 10(6)) in a concentration dependent manner. This indicated that CsB-851 could inhibit thrombus formation at the de-endotheliazed surface of the aorta. Since it could inhibit platelet aggregation in vitro had no effect on coagulation function in vivo, it seemed that the inhibitory effect of CsB-851 on arterial thrombus formation was mainly related to the inhibition of platelet functions.
将去内皮兔的主动脉血栓形成和51Cr标记的自体血小板用于评估CsB - 851对血小板 - 血管壁相互作用的体内效应。结果显示，当静脉输注CsB - 851（中华虫草菌丝体乙醇提取物的活性部分）时，每克损伤腹主动脉干重中51Cr标记的血小板数量（98.14±9.41×10(6)）以浓度依赖方式显著低于对照组（201.25±27.21×10(6)）。这表明CsB - 851可抑制主动脉去内皮表面的血栓形成。由于它在体外能抑制血小板聚集而对体内凝血功能无影响，似乎CsB - 851对动脉血栓形成的抑制作用主要与抑制血小板功能有关。
