轻度哮喘患儿的咳嗽频率与痰液中性粒细胞计数相关。
Cough frequency in children with mild asthma correlates with sputum neutrophil count.
作者信息
Li A M, Tsang T W T, Chan D F Y, Lam H S, So H K, Sung R Y T, Fok T F
机构信息
Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.
出版信息
Thorax. 2006 Sep;61(9):747-50. doi: 10.1136/thx.2005.050815. Epub 2006 May 2.
BACKGROUND
A study was undertaken to measure cough frequency in children with stable asthma using a validated monitoring device, and to assess the correlation between cough frequency and the degree and type of airway inflammation.
METHODS
Thirty six children of median age 11.5 years (interquartile range (IQR) 9-14) with stable asthma were recruited. They underwent spirometric testing, exhaled nitric oxide (eNO) measurement, sputum induction for differential cell count, and ambulatory cough monitoring for 24 hours. Coughing episodes were counted both as individual spikes and as clusters.
RESULTS
All children had mild intermittent asthma and their median forced expiratory volume in 1 second and eNO were 83.3% (IQR 81.1-97.6) and 56.1 ppb (IQR 37.4-105), respectively. The median number of cough episodes per day was 25.5 (IQR 16-42.8). Sputum induction was successful in 69% of the subjects and cough frequency was found to have a significant positive correlation with sputum neutrophil count (r = 0.833, p = 0.0001).
CONCLUSIONS
Children with stable mild asthma have increased cough frequency that might be driven by a neutrophilic inflammatory pathway.
背景
采用经过验证的监测设备对稳定期哮喘患儿的咳嗽频率进行测量，并评估咳嗽频率与气道炎症程度及类型之间的相关性。
方法
招募了36名年龄中位数为11.5岁（四分位间距（IQR）9 - 14岁）的稳定期哮喘患儿。他们接受了肺功能测试、呼出一氧化氮（eNO）测量、诱导痰液进行细胞分类计数以及24小时动态咳嗽监测。咳嗽发作既按单个峰值计数，也按簇计数。
结果
所有患儿均为轻度间歇性哮喘，其一秒用力呼气容积中位数和eNO分别为83.3%（IQR 81.1 - 97.6）和56.1 ppb（IQR 37.4 - 105）。每日咳嗽发作次数中位数为25.5（IQR 16 - 42.8）。69%的受试者诱导痰液成功，发现咳嗽频率与痰液中性粒细胞计数呈显著正相关（r = 0.833，p = 0.0001）。
结论
稳定期轻度哮喘患儿咳嗽频率增加，可能由中性粒细胞炎症途径驱动。
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