Bolan Patrick J, Yacoub Essa, Garwood Michael, Ugurbil Kamil, Harel Noam
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, 2021 Sixth Street SE, Minneapolis, MN 55455, USA.
Neuroimage. 2006 Aug 1;32(1):62-9. doi: 10.1016/j.neuroimage.2006.03.027. Epub 2006 May 3.
This work describes a methodology for in vivo MR imaging of arteries and veins within the visual cortex of the cat brain. Very high magnetic fields (9.4 T) and small field-of-view 3D acquisitions were used to image the neurovasculature at resolutions approaching the microscopic scale. A combination of time-of-flight MR angiography and T*(2)-weighted imaging, using both endogenous BOLD contrast and an exogenous iron-oxide contrast agent, provided high specificity for distinguishing between arteries and veins within the cortex. These acquisition techniques, combined with 3D image processing and display methods, were used to detect and visualize intracortical arteries and veins with diameters smaller than 100 microm. This methodology can be used for visualizing the neurovasculature or building models of the vascular network and may benefit a variety of research applications including fMRI, cerebrovascular disease and cancer angiogenesis.
这项工作描述了一种用于猫脑视觉皮层内动脉和静脉的体内磁共振成像方法。使用非常高的磁场（9.4 T）和小视野三维采集，以接近微观尺度的分辨率对神经血管系统进行成像。飞行时间磁共振血管造影和T*(2)加权成像相结合，同时使用内源性血氧水平依赖对比和外源性氧化铁对比剂，为区分皮层内的动脉和静脉提供了高特异性。这些采集技术与三维图像处理和显示方法相结合，用于检测和可视化直径小于100微米的皮层内动脉和静脉。这种方法可用于可视化神经血管系统或构建血管网络模型，并可能有益于包括功能磁共振成像、脑血管疾病和癌症血管生成在内的各种研究应用。
