Sargolini Francesca, Fyhn Marianne, Hafting Torkel, McNaughton Bruce L, Witter Menno P, Moser May-Britt, Moser Edvard I
Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
Science. 2006 May 5;312(5774):758-62. doi: 10.1126/science.1125572.
Grid cells in the medial entorhinal cortex (MEC) are part of an environment-independent spatial coordinate system. To determine how information about location, direction, and distance is integrated in the grid-cell network, we recorded from each principal cell layer of MEC in rats that explored two-dimensional environments. Whereas layer II was predominated by grid cells, grid cells colocalized with head-direction cells and conjunctive grid x head-direction cells in the deeper layers. All cell types were modulated by running speed. The conjunction of positional, directional, and translational information in a single MEC cell type may enable grid coordinates to be updated during self-motion-based navigation.
内侧内嗅皮质（MEC）中的网格细胞是一个与环境无关的空间坐标系的一部分。为了确定位置、方向和距离信息如何在网格细胞网络中整合，我们在探索二维环境的大鼠的MEC每个主细胞层进行了记录。虽然II层主要是网格细胞，但在较深层中，网格细胞与头部方向细胞以及联合网格x头部方向细胞共定位。所有细胞类型都受奔跑速度的调节。单一MEC细胞类型中位置、方向和平移信息的结合可能使网格坐标在基于自身运动的导航过程中得以更新。
