大脑中的体内13C核磁共振波谱学与代谢建模：实践视角
In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective.
作者信息
Henry Pierre-Gilles, Adriany Gregor, Deelchand Dinesh, Gruetter Rolf, Marjanska Malgorzata, Oz Gülin, Seaquist Elizabeth R, Shestov Alexander, Uğurbil Kâmil
机构信息
Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA.
出版信息
Magn Reson Imaging. 2006 May;24(4):527-39. doi: 10.1016/j.mri.2006.01.003. Epub 2006 Feb 20.
In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues.
体内13C核磁共振波谱具有在大脑中无创测量代谢通量的独特能力。代谢通量的定量测量需要用代谢模型对实验获得的13C标记时间进程进行分析。本工作回顾了动态代谢建模研究所需的要素，特别强调了实际问题。
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