Pahlavan Payam S, Kanthan Rani
Department of Physiology and Pathophysiology, University of Heidelberg, Germany.
J Gastrointestin Liver Dis. 2006 Mar;15(1):15-9.
This study was performed to evaluate the prevalence, clinical features and management of patients with colorectal cancer (CRC) in Iran.
All cases of CRC presented to a principal referral University hospital (SGH) for cancers in Teheran, Iran between June 20, 2000 and January 3, 2003 were retrospectively reviewed.
A total of 200 patients were included. 114 patients (57%) were male and 86 were female (43%). Age ranged from 13-90 years with a mean of 55.15 +/- 14.5. Among these patients, 16.5% were less than 40 years of age. The tumors were categorized according to their distribution as appendix (n=4), cecum ( n=7), right colon (n=1), hepatic flexure (n=2), transverse colon (n=19), splenic flexure (n=3), left colon (n=6), sigmoid ( n=16), rectum (n=117), rectosigmoid and rectal lesions (n=16), and colorectal lesions without known locations (n=9). Non-mucinous adenocarcinoma (AC) was the most common histological type (n=181, 90%), followed by mucinous AC (n=15), squamous cell carcinoma (n=1), carcinoid (n=1), melanoma (n=1) and signet ring carcinoma (n=1). The most common presenting symptom was rectal bleeding (n=68, 34.5%). Younger patients had a greater preponderance of mucinous AC (p=0.008) and generally underwent more extensive chemotherapy as seen with more usage of 5-Fluorouracil (p=0.05).
We have had few reports with reference to the epidemiology of CRC in Iran since 1977. The current data suggest a younger age distribution for CRC. We found no significant difference between age, gender and type of cancer with subsite distribution. Distal CRC was more prevalent. Among patients, 30.5% were diagnosed by screening studies.
本研究旨在评估伊朗结直肠癌（CRC）患者的患病率、临床特征及治疗情况。
回顾性分析2000年6月20日至2003年1月3日期间，在伊朗德黑兰一家主要的癌症转诊大学医院（SGH）就诊的所有CRC病例。
共纳入200例患者。其中男性114例（57%），女性86例（43%）。年龄范围为13至90岁，平均年龄为55.15±14.5岁。其中，16.5%的患者年龄小于40岁。肿瘤根据其分布情况分类为阑尾（n = 4）、盲肠（n = 7）、右半结肠（n = 1）、肝曲（n = 2）、横结肠（n = 19）、脾曲（n = 3）、左半结肠（n = 6）、乙状结肠（n = 16）、直肠（n = 117）、直肠乙状结肠和直肠病变（n = 16）以及部位不明的结直肠病变（n = 9）。非黏液腺癌（AC）是最常见的组织学类型（n = 181，90%），其次是黏液性AC（n = 15）、鳞状细胞癌（n = 1）、类癌（n = 1）、黑色素瘤（n = 1）和印戒细胞癌（n = 1）。最常见的症状是直肠出血（n = 68，34.5%）。年轻患者黏液性AC的比例更高（p = 0.008），并且通常接受更广泛的化疗，5-氟尿嘧啶的使用频率更高（p = 0.05）。
自1977年以来，关于伊朗CRC流行病学的报道较少。目前的数据表明CRC患者的年龄分布更年轻。我们发现年龄、性别和癌症类型与亚部位分布之间没有显著差异。远端CRC更为普遍。在患者中，30.5%是通过筛查研究确诊的。
