Bell Morris D, Bryson Gary J, Greig Tamasine C, Fiszdon Joanna M, Wexler Bruce E
Department of Veterans Affairs (VA) Connecticut Healthcare System, West Haven, CT, USA.
J Rehabil Res Dev. 2005 Nov-Dec;42(6):829-38. doi: 10.1682/jrrd.2005.03.0061.
Neurocognitive enhancement therapy (NET), which involves computerized cognitive training and other methods, has been shown to improve working memory and executive function in schizophrenia. In the present study, 145 outpatients with diagnoses of schizophrenia or schizoaffective disorder recruited from a Department of Veterans Affairs mental hygiene clinic and from a community mental health center were ran domized to 6 months of paid work therapy (WT) or to NET+WT. Mixed random effects analyses revealed significant increase in hours worked and money earned over time for both conditions (p < 0.0001). NET+WT worked more hours than WT (p < 0.03), with differences emerging after rehabilitation. Responders to NET+WT worked the most during follow-up and tended to have more competitive-wage employment. Results indicate that work outcomes were enhanced by NET training. Effects were greatest for NET responders. Findings support the efficacy of cognitive training when it is integrated into broader rehabilitation programs.
神经认知增强疗法（NET），包括计算机化认知训练和其他方法，已被证明可改善精神分裂症患者的工作记忆和执行功能。在本研究中，从退伍军人事务部精神卫生诊所和社区心理健康中心招募的145名诊断为精神分裂症或分裂情感性障碍的门诊患者被随机分为接受6个月有偿工作疗法（WT）或NET+WT。混合随机效应分析显示，两种情况下工作时长和收入随时间均显著增加（p<0.0001）。NET+WT的工作时长比WT更多（p<0.03），差异在康复后出现。对NET+WT有反应者在随访期间工作最多，且往往有薪酬更高的工作。结果表明，NET训练可改善工作成果。对NET有反应者的效果最佳。研究结果支持将认知训练纳入更广泛康复项目时的有效性。
