Krust K S, Drisko C L, Gross K, Overman P, Tira D E
University of Missouri-Kansas City School of Dentistry.
J Dent Hyg. 1991 Jul-Aug;65(6):289-95.
This pilot study compared the effectiveness of subgingival irrigation with 0.12% chlorhexidine, 1.64% stannous fluoride, and sterile saline, in addition to scaling and root planing, on levels of Bacteroides porphyromonas and the clinical parameters bleeding tendency, probing depth, and attachment level. A convenience sample of eight patients, exhibiting 32 sites with moderate periodontal disease, was randomly assigned to receive all treatments according to a four-quadrant treatment design. Subgingival irrigation was performed at 0, 1, 2, and 3 weeks following scaling and root planing. Clinical and microbial assessments were measured at baseline, 4, 8, and 12 weeks. Data were analyzed using a two-factor repeated measure analysis of variance, and the Newman-Keuls sequential range test or Friedman test and Kruskal-Wallis test revealed statistically significant (p less than .01) improvements in probing depths, attachment levels, and Bacteroides porphyromonas for all groups at 12 weeks when compared to baseline values. No statistically significant differences occurred between any of the treatment groups at any time period. Based on the findings of this investigation, it has been concluded that four weekly irrigations with 0.12% chlorhexidine, 1.64% stannous fluoride, or saline irrigation did not enhance the beneficial effects of scaling and root planing alone.
这项初步研究比较了除龈下刮治和根面平整外，使用0.12%氯己定、1.64%氟化亚锡和无菌生理盐水进行龈下冲洗，对牙龈卟啉单胞菌水平以及临床参数出血倾向、探诊深度和附着水平的效果。选取了8例患有中度牙周病、共32个部位的患者作为便利样本，根据四象限治疗设计随机分配接受所有治疗。在龈下刮治和根面平整后的第0、1、2和3周进行龈下冲洗。在基线、第4、8和12周进行临床和微生物评估。数据采用双因素重复测量方差分析进行分析，纽曼-基尔斯序贯极差检验或弗里德曼检验以及克鲁斯卡尔-沃利斯检验显示，与基线值相比，所有组在12周时探诊深度、附着水平和牙龈卟啉单胞菌均有统计学显著改善（p小于0.01）。在任何时间段，任何治疗组之间均未出现统计学显著差异。基于本研究的结果，得出结论：每周用0.12%氯己定、1.64%氟化亚锡或生理盐水冲洗四次，并不会增强单纯龈下刮治和根面平整的有益效果。
