O'Lorcain P, Deady S, Comber H
National Cancer Registry, Cork, Ireland.
Colorectal Dis. 2006 Jun;8(5):393-401. doi: 10.1111/j.1463-1318.2006.00951.x.
Colorectal cancer mortality predictions for Ireland are presented for all ages and for the age group 0-64 years.
Log and log-linear Poisson regression modelling was fitted to colorectal cancer mortality data for each year between 1950 and 2002 to predict average European age standardized mortality rates (EASMRs) per 100,000 person years (100,000 PY(-1)) and average numbers of deaths.
EASMRs for colon cancer are predicted to fall to 17.3 100,000 PY(-1) (95%PI 14.4, 20.2) in men and to 8.4 100,000 PY(-1) (95%PI 6.9, 10.2) in women by 2013-17. EASMRs for anorectal cancer are also predicted to fall to 8.0 100,000 PY(-1) (95%PI 6.6, 9.5) in men and to 3.0 100,000 PY(-1) (95%PI 2.3, 3.8) in women by this time. Truncated EASMRs for colon cancer for those aged between 0 and 64 years are predicted over the next 15 years to fall from their current levels to 4.4 100,000 PY(-1) (95%PI 3.0, 5.8) in men and to 2.3 100,000 PY(-1) (95%PI 1.5, 3.2) in women. For anorectal cancer, truncated EASMRs for those aged between 0 and 64 years are also predicted over the next 15 years to fall from their current levels to 2.9 100,000 PY(-1) (95%PI 2.0, 3.8) in men and to 0.9 100,000 PY(-1) (95%PI 0.4, 1.3) in women.
Ireland currently has one of the highest colorectal mortality rates in the developed world but recent downward trends, the advent of new screening tests and well targeted public health promotion programmes may lead to further reductions.
呈现爱尔兰所有年龄段以及0 - 64岁年龄组的结直肠癌死亡率预测情况。
对1950年至2002年每年的结直肠癌死亡率数据进行对数和对数线性泊松回归建模,以预测每10万人年的平均欧洲年龄标准化死亡率(EASMRs)以及平均死亡人数。
预计到2013 - 2017年,男性结肠癌的EASMRs将降至17.3/10万/人年(95%可信区间14.4,20.2),女性将降至8.4/10万/人年(95%可信区间6.9,10.2)。肛管癌的EASMRs预计到那时男性也将降至8.0/10万/人年(95%可信区间6.6,9.5),女性将降至3.0/10万/人年(95%可信区间2.3,3.8)。预计在未来15年,0至64岁人群结肠癌的截断EASMRs将从当前水平降至男性4.4/10万/人年(95%可信区间3.0,5.8),女性2.3/10万/人年(95%可信区间1.5,3.2)。对于肛管癌,0至64岁人群的截断EASMRs预计在未来15年也将从当前水平降至男性2.9/10万/人年(95%可信区间2.0,3.8),女性0.9/10万/人年(95%可信区间0.4,1.3)。
爱尔兰目前是发达国家中结直肠癌死亡率最高的国家之一,但近期的下降趋势、新筛查测试的出现以及针对性强的公共卫生促进项目可能会导致进一步降低。