Sheeja K, Shihab P K, Kuttan G
Amala Cancer Research Centre, Thrissur, Kerala, India.
Immunopharmacol Immunotoxicol. 2006;28(1):129-40. doi: 10.1080/08923970600626007.
In this study, we explored the antioxidant and anti-inflammatory properties of the medicinal herb Andrographis paniculata using in vitro as well as in vivo systems. Methanolic extract of Andrographis paniculata was found to inhibit formation of oxygen derived free radicals such as superoxide (32%) hydroxyl radicals (80%) lipid peroxidation (80%) and nitric oxide (42.8%) in in vitro system. In vivo studies using BALB/c mice models also showed significant inhibition in PMA induced superoxide (32.4%) and nitric oxide (65.3%) formation. Interestingly we also found that, administration of Andrographis paniculata extract produced complete inhibition of carageenan induced inflammation compared with control models.
在本研究中，我们利用体外及体内系统探究了药用植物穿心莲的抗氧化和抗炎特性。在体外系统中，发现穿心莲的甲醇提取物能够抑制氧衍生自由基的形成，如超氧化物（32%）、羟基自由基（80%）、脂质过氧化（80%）和一氧化氮（42.8%）。使用BALB/c小鼠模型进行的体内研究也显示，对佛波酯诱导的超氧化物（32.4%）和一氧化氮（65.3%）形成有显著抑制作用。有趣的是，我们还发现，与对照模型相比，给予穿心莲提取物可完全抑制角叉菜胶诱导的炎症。
