Pinto Jayant M, Elwany Samy, Baroody Fuad M, Naclerio Robert M
Section of Otolaryngology-Head and Neck Surgery, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA.
Am J Rhinol. 2006 Mar-Apr;20(2):191-6.
Topical saline is commonly recommended after endoscopic sinus surgery. The efficacy in this situation has never been shown.
We performed a controlled clinical trial to determine the effect of saline sprays on symptoms after endoscopic sinus surgery. Patients were randomized to receive normal saline (NS; n = 20), buffered hypertonic saline (HS; n = 20), or no spray (n = 20). A questionnaire measured symptoms of nasal obstruction, discharge, pain, headache, and trouble sleeping. Daily pain medication usage was recorded.
Symptom scores over the first 5 postoperative days showed higher nasal discharge scores in the HS group. Day-by-day comparisons showed that the HS group reported significantly higher pain scores during some postoperative days. The NS group showed similar scores to control.
NS and HS sprays do not have a beneficial effect on symptoms compared with no treatment. HS sprays enhanced nasal drainage and pain. Our results do not support prescribing saline sprays early after sinus surgery but do not exclude the use of topical saline in other forms or for other uses, although they may be used for other intentions.
内镜鼻窦手术后通常推荐使用局部生理盐水。但这种情况下其疗效从未得到证实。
我们进行了一项对照临床试验，以确定生理盐水喷雾对内窥镜鼻窦手术后症状的影响。患者被随机分为三组，分别接受生理盐水（NS；n = 20）、缓冲高渗盐水（HS；n = 20）喷雾治疗，或不接受喷雾治疗（n = 20）。通过问卷调查评估鼻塞、流涕、疼痛、头痛和睡眠障碍等症状。记录每日止痛药物的使用情况。
术后第1至5天的症状评分显示，HS组的流涕评分较高。逐日比较显示，HS组在术后某些日子的疼痛评分显著更高。NS组的评分与对照组相似。
与不治疗相比，NS和HS喷雾对症状没有有益影响。HS喷雾增加了鼻腔引流并加重了疼痛。我们的结果不支持在鼻窦手术后早期使用生理盐水喷雾，但不排除以其他形式或用于其他用途使用局部生理盐水，尽管它们可能用于其他目的。
