Shoseyov D, Bibi H, Shai P, Shoseyov N, Shazberg G, Hurvitz H
Pediatric Department, Bikur Cholim Hospital, Hadassa Medical School, Jerusalem, Israel.
J Allergy Clin Immunol. 1998 May;101(5):602-5. doi: 10.1016/S0091-6749(98)70166-6.
Chronic sinusitis (CS) is a common disease in children, especially those with allergies, that is caused by impaired drainage from the sinuses. Hypertonic NaCl solution has been shown to increase mucociliary clearance and ciliary beat frequency.
We performed a randomized double blind study to compare the effect of nasal wash with hypertonic saline (HS) (3.5%) versus normal saline (NS) (0.9%) on CS.
Thirty patients with CS aged 3 to 16 years were studied. They were randomly divided into two treatment groups matched by age and severity of the disease. Each individual was treated with either HS or NS for 4 weeks. All patients were evaluated by two clinical scores (cough and nasal secretions/postnasal drip [PND]) and by a radiology score at the beginning of the study and after 4 weeks.
The HS group improved significantly in all scores (average +/- SD): cough score, from 3.6 +/- 0.51 to 1.6 +/- 0.74; nasal secretion/PND score, from 2.86 +/- 0.35 to 1.6 +/- 0.74; and radiology score, from 8.06 +/- 1.28 to 2.66 +/- 1.04. The NS treatment group showed significant improvement only in the PND score (from 2.66 +/- 0.49 to 1.53 +/- 0.83) but no significant change in both the cough score (from 3.53 +/- 0.52 to 3.33 +/- 0.49) and the radiology score (from 8.13 +/- 1.25 to 7.86 +/- 0.91). Clinical observation 1 month after the end of the study showed no change compared with the end of the study in both groups.
HS nasal wash is an efficient treatment of CS.
慢性鼻窦炎（CS）是儿童常见疾病，尤其是在过敏儿童中，由鼻窦引流受损引起。高渗氯化钠溶液已被证明可增加黏液纤毛清除率和纤毛摆动频率。
我们进行了一项随机双盲研究，比较高渗盐水（HS）（3.5%）与生理盐水（NS）（0.9%）鼻腔冲洗对慢性鼻窦炎的效果。
研究了30例3至16岁的慢性鼻窦炎患者。他们被随机分为两个治疗组，根据年龄和疾病严重程度进行匹配。每个个体接受HS或NS治疗4周。在研究开始时和4周后，所有患者通过两个临床评分（咳嗽和鼻分泌物/鼻后滴漏[PND]）和一个放射学评分进行评估。
HS组在所有评分中均有显著改善（平均值±标准差）：咳嗽评分从3.6±0.51降至1.6±0.74；鼻分泌物/PND评分从2.86±0.35降至1.6±0.74；放射学评分从8.06±1.28降至2.66±1.04。NS治疗组仅在PND评分上有显著改善（从2.66±0.49降至1.53±0.83），但咳嗽评分（从3.53±0.52降至3.33±0.49）和放射学评分（从8.13±1.25降至7.86±0.91）均无显著变化。研究结束后1个月的临床观察显示，两组与研究结束时相比均无变化。
高渗盐水鼻腔冲洗是治疗慢性鼻窦炎的有效方法。
