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聚二甲基硅氧烷(PDMS)的亲水性互穿聚合物网络作为用于人工耳蜗的生物材料。

Hydrophilic interpenetrating polymer networks of poly(dimethyl siloxane) (PDMS) as biomaterial for cochlear implants.

作者信息

Abbasi F, Mirzadeh H, Simjoo M

机构信息

Research Centerfor Polymeric Materials, Sahand University of Technology, Tabriz, Iran.

出版信息

J Biomater Sci Polym Ed. 2006;17(3):341-55. doi: 10.1163/156856206775997287.

Abstract

Poly(dimethyl siloxane) (PDMS) was bulk-modified to develop a new intra-cochlear electrode that can closely hug the inner wall of scala tympani (ST). The hydrophilicity of bulk and surface of PDMS was changed using a sequential method for preparation of interpenetrating polymer networks (IPNs). A series of IPNs, based on PDMS and poly(acrylic acid) (PAAc), was synthesized and characterized by means of attenuated total reflectance Fourier transform infrared spectroscopy, water contact-angle measurement, dynamic mechanical thermal analysis and peel strength tests. The performances of actual-sized fabricated electrodes were assessed inside a transparent model of ST, which was filled with saline. The cell behavior of L929 fibroblasts on materials was studied in vitro.

摘要

聚二甲基硅氧烷(PDMS)经过本体改性,以开发一种能够紧密贴合鼓阶(ST)内壁的新型人工耳蜗电极。采用制备互穿聚合物网络(IPN)的顺序方法改变了PDMS本体和表面的亲水性。合成了一系列基于PDMS和聚丙烯酸(PAAc)的IPN,并通过衰减全反射傅里叶变换红外光谱、水接触角测量、动态机械热分析和剥离强度测试对其进行了表征。在充满盐水的ST透明模型内评估了实际尺寸制造电极的性能。在体外研究了L929成纤维细胞在材料上的细胞行为。

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