Keskin Damla, Mokabbar Taraneh, Pei Yutao, Van Rijn Patrick
University Medical Center Groningen, Department of Biomedical Engineering-FB40, W.J. Kolff Institute for Biomedical Engineering and Materials Science-FB41, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Engineering and Technology Institute Groningen, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Polymers (Basel). 2018 May 16;10(5):534. doi: 10.3390/polym10050534.
Polydimethylsiloxane (PDMS) is a silicone elastomer-based material that is used in various applications, including coatings, tubing, microfluidics, and medical implants. PDMS has been modified with hydrogel coatings to prevent fouling, which can be done through UV-mediated free radical polymerization using benzophenone. However, to the best of our knowledge, the properties of hydrogel coatings and their influence on the bulk properties of PDMS under various preparation conditions, such as the type and concentration of monomers, and UV treatment time, have never been investigated. Acrylate-based monomers were used to perform free radical polymerization on PDMS surfaces under various reaction conditions. This approach provides insights into the relationship between the hydrogel coating and bulk properties of PDMS. Altering the UV polymerization time and the monomer concentration resulted in different morphologies with different roughness and thickness of the hydrogel coating, as well as differences in the bulk material stiffness. The surface morphology of the coated PDMS was characterized by AFM. The cross section and thickness of the coatings were examined using scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy. The dependence of coating development on the monomer type and concentration used was evaluated by surface hydrophilicity, as measured by water contact angle. Elongation-until-break analysis revealed that specific reaction conditions affected the bulk properties and made the coated PDMS brittle. Therefore, boundary conditions have been identified to enable high quality hydrogel coating formation without affecting the bulk properties of the material.
聚二甲基硅氧烷（PDMS）是一种基于有机硅弹性体的材料，用于各种应用，包括涂层、管材、微流体和医疗植入物。PDMS已通过水凝胶涂层进行改性以防止污垢形成，这可以通过使用二苯甲酮的紫外线介导自由基聚合来实现。然而，据我们所知，水凝胶涂层的性能及其在各种制备条件下（如单体的类型和浓度以及紫外线处理时间）对PDMS整体性能的影响从未被研究过。在各种反应条件下，使用丙烯酸酯类单体在PDMS表面进行自由基聚合。这种方法有助于深入了解水凝胶涂层与PDMS整体性能之间的关系。改变紫外线聚合时间和单体浓度会导致水凝胶涂层具有不同的粗糙度和厚度，从而呈现出不同的形态，同时材料的整体刚度也会有所不同。通过原子力显微镜（AFM）对涂覆PDMS的表面形态进行了表征。使用扫描电子显微镜结合能量色散X射线光谱仪对涂层的横截面和厚度进行了检查。通过测量水接触角来评估涂层形成对所用单体类型和浓度的依赖性，以此衡量表面亲水性。断裂伸长率分析表明，特定的反应条件会影响材料的整体性能，使涂覆的PDMS变脆。因此，已经确定了边界条件，以实现高质量的水凝胶涂层形成，同时不影响材料的整体性能。
