Otto T, Eichenbaum H, Wiener S I, Wible C G
Department of Biological Sciences, Wellesley College, MA 02181.
Hippocampus. 1991 Apr;1(2):181-92. doi: 10.1002/hipo.450010206.
Recent studies have revealed 3 stimulation parameters that together comprise the temporal pattern of neuronal activation optimal for the induction of hippocampal LTP: high-frequency bursts, activity 100-200 ms prior to a burst, and burst delivery in phase with the ongoing hippocampal theta rhythm. The present paper reports that these 3 aspects of patterned neural activity, collectively referred to as "theta-bursting," are characteristic of the spike trains of CA1 pyramidal cells in rats during the sampling and analysis of learning cues in an odor discrimination task and during performances of a spatial memory task. In contrast, theta-bursting occurs relatively infrequently during behavioral events less directly related to task-relevant mnemonic processing. These findings suggest that the optimal conditions for the induction of LTP occur naturally in behaving animals, time-locked to behavioral events critical to learning.
最近的研究揭示了3种刺激参数，它们共同构成了诱导海马体LTP（长时程增强）的最佳神经元激活时间模式：高频爆发、爆发前100 - 200毫秒的活动以及与正在进行的海马体θ节律同步的爆发传递。本文报道，这种模式化神经活动的这3个方面，统称为“θ爆发”，是大鼠在气味辨别任务中学习线索的采样和分析过程以及空间记忆任务执行过程中CA1锥体神经元的放电序列特征。相比之下，在与任务相关的记忆处理不太直接相关的行为事件中，θ爆发相对较少发生。这些发现表明，诱导LTP的最佳条件在行为动物中自然出现，与对学习至关重要的行为事件时间锁定。
