Tuite Ashleigh, Gros Philippe
Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Room 907, Montreal, QC H3G 1Y6, Canada.
Microbes Infect. 2006 May;8(6):1647-53. doi: 10.1016/j.micinf.2005.11.016. Epub 2006 Jan 26.
The advent of new technologies and resources, including the complete sequence of mammalian genomes, has had a dramatic impact on the genetic analysis of susceptibility to infections in humans and in animal models of infection. Genes responsible for simple or complex control of susceptibility to infection with different pathogens have been recently identified and characterized, and are reviewed herein.
包括哺乳动物基因组完整序列在内的新技术和资源的出现,对人类及感染动物模型中感染易感性的遗传分析产生了巨大影响。最近已鉴定并表征了负责简单或复杂控制对不同病原体感染易感性的基因,本文对此进行综述。