Nat Genet. 2010 Sep;42(9):731-2. doi: 10.1038/ng0910-731.
Two genome-wide association studies for meningococcal disease and tuberculosis identify new loci associated with susceptibility to these infectious diseases. They highlight a role for the acquired and innate immune systems in host control of several human pathogens and demonstrate that denser genotyping platforms and population-specific reference panels are necessary for genetic studies in African populations.
两项关于脑膜炎球菌病和结核病的全基因组关联研究确定了与这些传染病易感性相关的新基因座。它们强调了获得性和固有免疫系统在宿主控制几种人类病原体中的作用,并表明在非洲人群中进行遗传研究需要更密集的基因分型平台和特定于人群的参考面板。