Dhossche Dirk Marcel, Carroll Brendan T, Carroll Tressa D
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Int Rev Neurobiol. 2006;72:151-64. doi: 10.1016/S0074-7742(05)72009-2.
Neuronal bases for autism and catatonia are unknown although integrative theories may soon become feasible as research in autism and catatonia advances. Catatonia and autism may both qualify as neurobiological syndromes in their own right. There is emerging evidence that catatonia may be a common syndrome in autism. Although the relation between autism and catatonia is unclear, coexpression of autism and catatonia may be due to abnormalities in common neuronal circuitries. This possibility constitutes another level of complexity to neurobiological inquiry, but also provides an opportunity to advance our understanding of both disorders. There is a great potential benefit in studying the relation between catatonia and autism in order to focus future research on subtype-specific causes and treatments. Future research avenues are outlined.
尽管随着自闭症和紧张症研究的进展，整合理论可能很快变得可行，但自闭症和紧张症的神经元基础尚不清楚。紧张症和自闭症本身都可能有资格被视为神经生物学综合征。越来越多的证据表明，紧张症可能是自闭症中的一种常见综合征。虽然自闭症和紧张症之间的关系尚不清楚，但自闭症和紧张症的共同表现可能是由于共同神经回路的异常。这种可能性给神经生物学研究带来了另一个复杂层面，但也为增进我们对这两种疾病的理解提供了一个机会。研究紧张症和自闭症之间的关系具有很大的潜在益处，以便将未来的研究重点放在亚型特异性病因和治疗方法上。本文概述了未来的研究方向。
