Dell'Osso Liliana, Amatori Giulia, Carpita Barbara, Massimetti Gabriele, Nardi Benedetta, Gravina Davide, Benedetti Francesca, Bonelli Chiara, Casagrande Danila, Luciano Mario, Berardelli Isabella, Brondino Natascia, De Gregorio Marianna, Deste Giacomo, Nola Marta, Reitano Antonino, Muscatello Maria Rosaria Anna, Pompili Maurizio, Politi Pierluigi, Vita Antonio, Maj Mario
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Department of Psychiatry, University of Naples "Luigi Vanvitelli", Naples, Italy.
Front Psychiatry. 2023 Jul 20;14:1092193. doi: 10.3389/fpsyt.2023.1092193. eCollection 2023.
In the recent years, several studies have shown a correlation between autism spectrum disorder (ASD) and catatonia. It is also known that both conditions are found to be associated with mood disorders. This study aimed to investigate the relationship between autistic traits and catatonic symptoms, as well as the potential mediating role of mood disorder spectrum in the relationship between them.
The total sample of 514 subjects was composed by four diagnostic groups, composed by patients affected by catatonia (CTN), borderline personality disorder (BPD), major depressive disorder (MDD) and healthy controls (HC). Subjects were assessed with the SCID-5-RV, the Adult Autism Subthreshold Spectrum (AdAS Spectrum) and the Catatonia Spectrum (CS) and the Mood Spectrum Self-Report (MOODS-SR). Statistical analyses included Pearson's coefficient calculation, multiple linear regression, and mediation analysis.
all the correlations appear to be strongly positive and significant with the strongest coefficient emerging between AdAS Spectrum total score and CS total score ( = 0.762, < 0.001). The Mediation Analysis showed that AdAS Spectrum total score showed a significant indirect effect on CS total score through MOODS-SR total score ( = 0.168, 95% bootstrapped CI [0.127:0.207]).
The present study highlights the presence of a mediating role of the mood disorder spectrum in the relationship between autistic traits and the catatonia spectrum.
近年来，多项研究表明自闭症谱系障碍（ASD）与紧张症之间存在关联。众所周知，这两种病症都与情绪障碍有关。本研究旨在调查自闭症特征与紧张症症状之间的关系，以及情绪障碍谱系在它们之间关系中的潜在中介作用。
514名受试者的总样本由四个诊断组组成，分别为紧张症（CTN）患者、边缘性人格障碍（BPD）患者、重度抑郁症（MDD）患者和健康对照组（HC）。受试者接受了《精神疾病诊断与统计手册》第五版修订版（SCID-5-RV）、成人自闭症阈下谱系量表（AdAS Spectrum）、紧张症谱系量表（CS）和情绪谱系自评量表（MOODS-SR）的评估。统计分析包括皮尔逊系数计算、多元线性回归和中介分析。
所有相关性似乎都呈强正相关且具有显著性，其中AdAS Spectrum总分与CS总分之间的系数最强（r = 0.762，p < 0.001）。中介分析表明，AdAS Spectrum总分通过MOODS-SR总分对CS总分产生显著的间接效应（β = 0.168，95%自抽样置信区间[0.127:0.207]）。
本研究强调了情绪障碍谱系在自闭症特征与紧张症谱系之间的关系中起中介作用。
