Thanabhorn S, Jaijoy K, Thamaree S, Ingkaninan K, Panthong A
Department of Preclinical Science, Division of Pharmacology, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.
J Ethnopharmacol. 2006 Oct 11;107(3):370-3. doi: 10.1016/j.jep.2006.03.023. Epub 2006 Apr 6.
The ethanol extract from the leaves of Lonicera japonica Thunb. was evaluated for acute and subacute toxicity. The single oral dose of the ethanol extract at 5,000 mg/kg did not produce mortality or significant changes in the general behaviour and gross appearance of the internal organs of rats. In subacute toxicity study, the ethanol extract was administered orally at a dose of 1,000 mg/kg/day for a period of 14 days. The satellite group was treated with the ethanol extract at the same dose and the same period and kept for another 14 days after treatment. There were no significant differences in the body and organ weights between the control and the treated group of both sexes. Hematological analysis and clinical blood chemistry revealed no toxicity effects of the extract. Pathologically, neither gross abnormalities nor histopathological changes were observed.
对忍冬叶乙醇提取物进行了急性和亚急性毒性评估。大鼠单次口服剂量为5000mg/kg的乙醇提取物后，未出现死亡情况，大鼠的一般行为和内脏外观也未发生显著变化。在亚急性毒性研究中，乙醇提取物以1000mg/kg/天的剂量口服给药，持续14天。卫星组以相同剂量和相同时间给予乙醇提取物，并在治疗后再饲养14天。雌雄对照组和治疗组之间的体重和器官重量均无显著差异。血液学分析和临床血液生化检查显示该提取物无毒性作用。病理学检查未观察到大体异常或组织病理学变化。
