Lai J-N, Chen H-J, Chen C-M, Chen P-C, Wang J-D
Department of Obstetrics and Gynecology, Taipei Municipal Yang Ming Hospital, Taipei, Taiwan.
Climacteric. 2006 Apr;9(2):119-28. doi: 10.1080/13697130600635292.
To determine the impact of the climacteric transition on health-related quality of life amongst women, between the ages of 45 and 55 years, seeking medical advice in Taiwan.
A total of 203 women seeking medical advice (SMA) were drawn from a special integrated clinic, with a further 349 healthy referents of the same age, range and gender, with no history of hormone replacement therapy and living in the same municipality, also being recruited from a national health survey sample for comparison. Each one was asked to fill out the brief questionnaire of the Taiwan version of the World Health Organization Quality of Life (WHOQOL-BREF), assessing quality of life on 26 items in four domains (physical, psychological, social and environmental). SMA subjects were also questioned about the 21 most frequent symptoms. Multiple regression analyses were conducted to control variables such as age, marital status, religion and educational attainment.
The mean scores for the physical, psychological and social domains were significantly lower than those of the healthy referents, as was the overall quality of life for SMA women. Although usual vasomotor symptoms did not significantly predict quality of life in the SMA subjects, after controlling for demographic factors, insomnia and emotional disturbance were found to be major determinants of the scores in the different domains.
Insomnia and emotional disturbance should be taken into consideration in the management of climacteric women seeking medical advice.
确定更年期过渡对台湾地区45至55岁寻求医疗建议的女性健康相关生活质量的影响。
从一家特殊综合诊所选取了203名寻求医疗建议的女性（SMA），并从全国健康调查样本中招募了另外349名年龄、年龄范围和性别相同、无激素替代疗法史且居住在同一城市的健康对照者进行比较。要求每个人填写台湾版世界卫生组织生活质量简表（WHOQOL-BREF），该表在四个领域（身体、心理、社会和环境）对26个项目的生活质量进行评估。还询问了SMA受试者21种最常见的症状。进行多元回归分析以控制年龄、婚姻状况、宗教信仰和教育程度等变量。
SMA女性在身体、心理和社会领域的平均得分显著低于健康对照者，其总体生活质量也是如此。虽然常见的血管舒缩症状并不能显著预测SMA受试者的生活质量，但在控制人口统计学因素后，发现失眠和情绪障碍是不同领域得分的主要决定因素。
在对寻求医疗建议的更年期女性进行管理时，应考虑失眠和情绪障碍。
