Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
Evid Based Complement Alternat Med. 2011;2011:673813. doi: 10.1155/2011/673813. Epub 2011 May 10.
Little scientific evidence supports the efficacy of herbal medicines in the treatment of women with sleep difficulty during the climacteric period. The purpose of this study is to evaluate the efficacy and safety of Suan Zao Ren Tang (SZRT) in reducing the impact of sleep disturbance on climacteric women, as measured by Pittsburg sleep quality index (PSQI) and the World Health Organization quality of life (WHOQOL). Sixty-seven climacteric women with sleep difficulty intending to treat received SZRT at a rate of 4.0 g, thrice daily for four weeks (MRS < 16, n = 34; MRS ≥ 16, n = 33). After taking into account potential confounding factors, the mean PSQI total scores had fallen from 13.0 (±2.9) to 9.0 (±3.2) (95% confidence interval -4.93, -3.10). Further analyses showed that SZRT produced superior benefit of daytime dysfunction in women with severe menopausal symptoms (MRS ≥ 16). There were three of the withdrawals involved treatment-related adverse events (stomachache, diarrhea, and dizziness). Excluding women with a past history of stomachache, diarrhea, or dizziness, four weeks of therapy with SZRT appears to be a relatively safe and effective short-term therapeutic option in improving daytime function of climacteric women with poor sleep quality.
科学证据很少支持草药在治疗更年期睡眠困难女性方面的疗效。本研究旨在评估酸枣仁汤（SZRT）在减轻睡眠障碍对更年期女性的影响方面的疗效和安全性，通过匹兹堡睡眠质量指数（PSQI）和世界卫生组织生活质量（WHOQOL）来衡量。67 名有睡眠困难的更年期女性打算接受 SZRT 治疗，剂量为 4.0g，每日 3 次，持续四周（MRS<16，n=34；MRS≥16，n=33）。考虑到潜在的混杂因素后，PSQI 总分从 13.0（±2.9）降至 9.0（±3.2）（95%置信区间-4.93，-3.10）。进一步分析表明，SZRT 对更年期症状严重（MRS≥16）的女性白天功能障碍有更好的疗效。有 3 例因与治疗相关的不良反应（胃痛、腹泻和头晕）而退出。排除有胃痛、腹泻或头晕病史的女性后，四周的 SZRT 治疗似乎是一种相对安全有效的短期治疗选择，可以改善睡眠质量差的更年期女性白天的功能。
