伊朗南部布什尔献血者中戊型肝炎病毒血清流行率
Hepatitis E Virus Seroprevalence Among Blood Donors in Bushehr, South of Iran.
作者信息
Naeimi Behrouz, Mazloom Kalimani Farnaz, Pourfatolah Ali Akbar, Azimzadeh Masoud, Mankhian Alireza, Akbarzadeh Samad, Hajiani Gholamreza, Kooshesh Faramarz, Khamisipour Gholamreza
机构信息
Department of Microbiology and Parasitology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, IR Iran; The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, IR Iran.
Student Research Committee, Bushehr University of Medical Sciences, Bushehr, IR Iran.
出版信息
Hepat Mon. 2015 Nov 28;15(11):e29219. doi: 10.5812/hepatmon.29219. eCollection 2015 Nov.
BACKGROUND
Although so far several studies have determined the hepatitis E virus (HEV) prevalence in some parts of Iran, no data exists regarding the HEV seroprevalence in Bushehr province as the southernmost point in Iran yet.
OBJECTIVES
The aim of this study was to evaluate the seroprevalence of anti-HEV IgG among the blood donors in Bushehr.
PATIENTS AND METHODS
A total of 628 blood donor samples were collected from September to October 2013, after obtaining informed written consents, and analyzed for the presence of anti-HEV IgG using commercial HEV enzyme-linked immunosorbent assay (ELISA) kit. All the samples were tested by two ELISA kits and evaluated for liver function test.
RESULTS
Overall, 105 (16.7%) blood samples were positive for HEV-specific-IgG antibodies, while 523 (83.8%) were negative. The presence of anti-HEV IgG was not associated with gender; however, it was correlated with age. It was indicated that the anti-HEV prevalence increases by age and there was a significant difference between the age groups regarding HEV seropositivity.
CONCLUSIONS
High HEV seroprevalence (16.7%) was observed among the blood donors in Bushehr province. It appears that exposure to HEV increases with age; although, more people should be examined.
背景
尽管到目前为止已有多项研究确定了伊朗部分地区的戊型肝炎病毒（HEV）流行情况，但关于伊朗最南端的布什尔省的HEV血清流行率尚无数据。
目的
本研究旨在评估布什尔地区献血者中抗HEV IgG的血清流行率。
患者与方法
在获得知情书面同意后，于2013年9月至10月共采集了628份献血者样本，并使用商用HEV酶联免疫吸附测定（ELISA）试剂盒分析抗HEV IgG的存在情况。所有样本均通过两种ELISA试剂盒进行检测，并评估肝功能。
结果
总体而言，105份（16.7%）血样的HEV特异性IgG抗体呈阳性，而523份（83.8%）为阴性。抗HEV IgG的存在与性别无关；然而，它与年龄相关。结果表明，抗HEV流行率随年龄增长而增加，且各年龄组之间的HEV血清阳性率存在显著差异。
结论
在布什尔省的献血者中观察到较高的HEV血清流行率（16.7%）。似乎接触HEV的情况随年龄增加，不过，应该检查更多的人。
Zotero 插件