Vu Nguyen Trung, Le Van Phung, Le Huy Chinh, Weintraub Andrej
Department of Medical Microbiology, Hanoi Medical University, Hanoi, Vietnam.
Anaerobe. 2005 Feb-Apr;11(1-2):109-14. doi: 10.1016/j.anaerobe.2004.10.004. Epub 2004 Dec 9.
Enterotoxigenic Bacteroides fragilis (ETBF) are considered as an emerging enteropathogen causing diarrhea in children. Eight hundred and thirty-six (836) children less than 5 years of age including 587 children with diarrhea and 249 age-matched controls were involved in the study. Within the group of children with diarrhea, 7.3% (43/587) ETBF was detected by immunoseparation in combination with polymerase chain reaction. The corresponding figure for the controls was 2.4% (6/249) (P<0.01). Within the diarrhea group, the prevalence was significantly higher in children older than 1 year of age. Three subtypes of ETBF isolates have been identified with the prevalence of 67.4%, 18.6%, and 16% for bft-1, bft-2, and a new bft, respectively. In the controls, two of the subtypes were identified, 5 bft-1 and 1 bft-2. More than half (55.8%) of the samples harboring ETBF also had other identified pathogens. The clinical symptoms of the single ETBF infection were not different from those of co-infections. This is the first study of the role of ETBF in children's diarrhea in Vietnam and it is concluded that this pathogen is an important causative agent of diarrhea in children in Hanoi, Vietnam.
产肠毒素脆弱拟杆菌（ETBF）被认为是一种引发儿童腹泻的新出现的肠道病原体。该研究纳入了836名5岁以下儿童，其中包括587名腹泻儿童和249名年龄匹配的对照儿童。在腹泻儿童组中，通过免疫分离结合聚合酶链反应检测到7.3%（43/587）的ETBF。对照组的相应比例为2.4%（6/249）（P<0.01）。在腹泻组中，1岁以上儿童的患病率显著更高。已鉴定出ETBF分离株的三种亚型，bft-1、bft-2和一种新的bft的患病率分别为67.4%、18.6%和16%。在对照组中，鉴定出了两种亚型，5株bft-1和1株bft-2。携带ETBF的样本中超过一半（55.8%）还存在其他已鉴定的病原体。单一ETBF感染的临床症状与合并感染的症状没有差异。这是越南关于ETBF在儿童腹泻中作用的首次研究，得出的结论是，这种病原体是越南河内儿童腹泻的重要致病因素。
