Goldstein Stuart L, Graham Nicole, Burwinkle Tasha, Warady Bradley, Farrah Rhonda, Varni James W
Texas Children's Hospital, 6621 Fannin Street, MC 3-2482, Houston, TX 77030, USA.
Pediatr Nephrol. 2006 Jun;21(6):846-50. doi: 10.1007/s00467-006-0081-y. Epub 2006 Apr 20.
As part of creating a pediatric ESRD-specific Health-Related Quality of Life (HRQOL) assessment instrument, we established pilot data with the PedsQL 4.0 Generic Core Scales in 96 pediatric patients with ESRD receiving hemodialysis (HD), peritoneal dialysis (PD) or with a renal transplant (TX). Patient age ranges were: 2-4 (8; PD n=3, TX n=5), 5-7 (12; HD n=9, TX n=3), 8-12 (25; HD n=5, PD n=6, TX n=14), 13-18 (51; HD n=18, PD n=10, TX n=23). PedsQL ESRD data were compared to healthy children (n=131 child report; n=145 parent report) and across HD/PD/TX. For all domains, ESRD patient HRQOL scores were significantly lower than healthy controls. Transplant patients reported better physical and psychosocial health than dialysis patients. No difference was noted between HD and PD patients for any PedsQL domain. Our data demonstrate that the PedsQL 4.0 Generic Core Scales is a useful measurement instrument to screen for HRQOL impairment in pediatric patients with ESRD. We suggest that the ESRD-specific HRQOL instrument in development is needed to help define condition-specific HRQOL differences between modalities.
作为创建特定于儿科终末期肾病（ESRD）的健康相关生活质量（HRQOL）评估工具的一部分，我们在96例接受血液透析（HD）、腹膜透析（PD）或肾移植（TX）的儿科ESRD患者中，使用儿童生活质量量表4.0通用核心量表建立了试点数据。患者年龄范围为：2 - 4岁（8例；PD组3例，TX组5例），5 - 7岁（12例；HD组9例，TX组3例），8 - 12岁（25例；HD组5例，PD组6例，TX组14例），13 - 18岁（51例；HD组18例，PD组10例，TX组23例）。将儿科ESRD数据与健康儿童（儿童报告131例；家长报告145例）进行比较，并在HD/PD/TX组之间进行比较。在所有领域，ESRD患者的HRQOL得分均显著低于健康对照组。移植患者报告的身体和心理社会健康状况优于透析患者。在任何儿童生活质量量表领域，HD和PD患者之间均未发现差异。我们的数据表明，儿童生活质量量表4.0通用核心量表是筛查儿科ESRD患者HRQOL损害的有用测量工具。我们建议，需要开发特定于ESRD的HRQOL工具，以帮助确定不同治疗方式之间特定疾病的HRQOL差异。
