红榄李根中的新型间苯三酚衍生物。

Novel phloroglucinol derivatives from the roots of Lysidice rhodostegia.

作者信息

Hu You-cai, Wu Xian-fu, Gao Song, Yu Shi-Shan, Liu Yue, Qu Jing, Liu Jing, Liu Yun-bao

机构信息

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Beijing, People's Republic of China.

出版信息

Org Lett. 2006 May 25;8(11):2269-72. doi: 10.1021/ol060514o.

DOI:10.1021/ol060514o

PMID:16706503

Abstract

[structure: see text] Three novel phloroglucinol derivatives of lysidicins A-C (1-3) have been isolated from the roots of Lysidice rhodostegia and structures were elucidated by comprehensive NMR and MS spectroscopic analysis. 1 and 2 possess spirocyclic benzodihydrofuran skeleton. Their relative stereochemistries were assigned by NOE or NOESY experiment. A plausible pathway for the biosynthesis of 1-3 from 4 and a ketose derivative was postulated.

摘要

[结构：见正文] 从红榄李的根部分离出了三种新的间苯三酚衍生物——异红榄李素A-C（1-3），并通过全面的核磁共振和质谱光谱分析阐明了其结构。1和2具有螺环苯并二氢呋喃骨架。它们的相对立体化学结构通过NOE或NOESY实验确定。推测了由4和一种酮糖衍生物生物合成1-3的可能途径。