从红榄李中分离得到的具有抗氧化活性的间苯三酚类化合物。

Phloroglucinols with Antioxidant Activities Isolated from Lysidice rhodostegia.

作者信息

Wu Xian-Fu, Li Li, Li Yong, Lv Hai-Ning, Liu Yun-Bao, Hu You-Cai

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

National Institutes for Food and Drug Control, Beijing 100050, China.

出版信息

Molecules. 2017 May 23;22(6):855. doi: 10.3390/molecules22060855.

DOI:10.3390/molecules22060855

PMID:28545244

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6152794/

Abstract

Two new phloroglucinols, lysidisides X and Y ( and ), and two known compounds, 2-(2-methylbutyryl)phloroglucinol 1--β-d-glucopyranoside () and ()-resveratrol 3-(6″-galloyl)--β-d-glucopyranoside (), have been isolated from the roots of . The structures of and were elucidated primarily by NMR experiments. Their absolute configurations were deduced via circular dichroism (CD) data and electronic circular dichroism (ECD) calculations. Compounds and exhibited significant antioxidative activities with IC values of 12.0 and 11.8 µM, respectively.

摘要

从[植物名称]的根部分离出了两种新的间苯三酚，lysidisides X和Y（[具体结构简式]），以及两种已知化合物，2-(2-甲基丁酰基)间苯三酚1--β-d-吡喃葡萄糖苷（[具体结构简式]）和（）-白藜芦醇3-(6″-没食子酰基)--β-d-吡喃葡萄糖苷（[具体结构简式]）。化合物[具体化合物]和[具体化合物]的结构主要通过核磁共振实验得以阐明。它们的绝对构型通过圆二色性（CD）数据和电子圆二色性（ECD）计算推导得出。化合物[具体化合物]和[具体化合物]表现出显著的抗氧化活性，其IC值分别为12.0和11.8 μM。