Budovsky Arie, Muradian Khachik K, Fraifeld Vadim E
Department of Microbiology and Immunology, Center for Multidisciplinary Research in Aging, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Rejuvenation Res. 2006 Summer;9(2):207-10. doi: 10.1089/rej.2006.9.207.
Aging should be considered a major risk factor for life-threatening degenerative pathologies including atherosclerosis, cancer, neurodegeneration, diabetes type II, osteoporosis, and sarcopenia. Although an apparent paradox, it appears that the most effective way to delay or even to avert age-related diseases is to live longer. Common changes in the epigenetic control of gene expression may be one of the central mechanisms behind both aging and age-associated pathologies. If so, epigenetic interventions may serve in a twofold manner: (a) to extend the lifespan and (b) cure age-related degenerative diseases. Currently predominant disease-oriented paradigm should be reconsidered toward aging/longevity oriented.
衰老应被视为包括动脉粥样硬化、癌症、神经退行性变、II型糖尿病、骨质疏松症和肌肉减少症在内的危及生命的退行性疾病的主要风险因素。尽管看似矛盾，但延缓甚至避免与年龄相关疾病的最有效方法似乎是活得更长。基因表达表观遗传控制中的常见变化可能是衰老和与年龄相关疾病背后的核心机制之一。如果是这样，表观遗传干预可能有双重作用：(a)延长寿命；(b)治愈与年龄相关的退行性疾病。当前以疾病为主导的主要范式应重新考虑为以衰老/长寿为导向。
