Vandergrift William A, Patel Sunil J, Nicholas Joyce S, Varma Abhay K
Division of Neurosurgery, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Neurosurg Focus. 2006 Apr 15;20(4):E13. doi: 10.3171/foc.2006.20.4.8.
The treatment of malignant gliomas has advanced significantly in the past 15 years. The simultaneous development of new targeting agents and techniques to deliver these high-molecular-weight compounds has led to improved efficacy and promising results in Phase III trials. Convection-enhanced delivery (CED) of macromolecules has emerged as the leading delivery technique for the treatment of malignant gliomas. A summary of the basic principles of CED and a review of the current human trials of protein targeting agents are provided.
在过去15年中，恶性胶质瘤的治疗取得了显著进展。新型靶向药物以及用于递送这些高分子量化合物的技术的同步发展，已提高了疗效，并在III期试验中取得了令人鼓舞的结果。大分子的对流增强递送（CED）已成为治疗恶性胶质瘤的主要递送技术。本文提供了CED的基本原理概述以及目前蛋白质靶向药物人体试验的综述。
