Crombleholme T M, Langer J C, Harrison M R, Zanjani E D
Department of Surgery, University of California, San Francisco 94143-0570.
Am J Obstet Gynecol. 1991 Jan;164(1 Pt 1):218-30. doi: 10.1016/0002-9378(91)90656-c.
Cellular transplantation is an attractive alternative to whole-organ transplantation when only a discrete function of the organ is deficient. Early fetal donor cells have an advantage because they engraft readily and do not cause graft-versus-host disease. Similarly, the fetus is an ideal recipient of allogeneic fetal cells as it is incapable of rejecting them early in gestation. This review presents the theoretical rationale, recent research advances, and clinical implications for adults with diabetes mellitus and Parkinson's disease; we also describe in utero transplantation of fetal hematopoietic stem cells and hepatocytes for the treatment of inherited hematologic and hepatic deficiencies, as well as the use of fetal islet cells and dopamine-producing cells to treat postnatal conditions.
当器官仅某一特定功能存在缺陷时，细胞移植是全器官移植的一种有吸引力的替代方法。早期胎儿供体细胞具有优势，因为它们易于植入且不会引起移植物抗宿主病。同样，胎儿是同种异体胎儿细胞的理想受体，因为它在妊娠早期无法排斥这些细胞。本综述介绍了针对成年糖尿病患者和帕金森病患者的理论依据、近期研究进展及临床意义；我们还描述了用于治疗遗传性血液和肝脏缺陷的胎儿造血干细胞和肝细胞的宫内移植，以及使用胎儿胰岛细胞和产生多巴胺的细胞治疗出生后疾病的情况。
