实体器官移植中爱泼斯坦-巴尔病毒通过供体器官的传播：IR2、IR3和IR4的聚合酶链反应及限制性片段长度多态性分析
Epstein-Barr virus transmission via the donor organs in solid organ transplantation: polymerase chain reaction and restriction fragment length polymorphism analysis of IR2, IR3, and IR4.
作者信息
Cen H, Breinig M C, Atchison R W, Ho M, McKnight J L
机构信息
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261.
出版信息
J Virol. 1991 Feb;65(2):976-80. doi: 10.1128/JVI.65.2.976-980.1991.
Abstract
Two organ transplant recipients who received organs from a common donor and were diagnosed as having an Epstein-Barr virus (EBV)-associated posttransplant lymphoproliferative disorder were studied to determine the mode of EBV transmission. The results of restriction fragment length polymorphism, polymerase chain reaction, and minisatellite DNA analyses demonstrate that both patients had a common strain of EBV and that this strain was transmitted from the donor's organs to both recipients. Posttransplant lymphoproliferative disorder resulted from the proliferation of EBV-immortalized B lymphocytes of the recipient, not those of the donor.
摘要
对两名接受来自同一供体器官移植且被诊断患有与爱泼斯坦-巴尔病毒（EBV）相关的移植后淋巴细胞增生性疾病的器官移植受者进行了研究，以确定EBV的传播方式。限制性片段长度多态性分析、聚合酶链反应和小卫星DNA分析结果表明，两名患者感染的是同一种EBV毒株，且该毒株是从供体器官传播给两名受者的。移植后淋巴细胞增生性疾病是由受者而非供者的EBV永生化B淋巴细胞增殖所致。
相似文献
1
Epstein-Barr virus transmission via the donor organs in solid organ transplantation: polymerase chain reaction and restriction fragment length polymorphism analysis of IR2, IR3, and IR4.实体器官移植中爱泼斯坦-巴尔病毒通过供体器官的传播：IR2、IR3和IR4的聚合酶链反应及限制性片段长度多态性分析
J Virol. 1991 Feb;65(2):976-80. doi: 10.1128/JVI.65.2.976-980.1991.
2
3
4
Transmission of donor Epstein-Barr virus (EBV) in transplanted organs causes lymphoproliferative disease in EBV-seronegative recipients.供体爱泼斯坦-巴尔病毒（EBV）在移植器官中的传播会导致EBV血清阴性受者发生淋巴增殖性疾病。
J Gen Virol. 1996 Jun;77 ( Pt 6):1169-72. doi: 10.1099/0022-1317-77-6-1169.
5
Detection of Epstein-Barr virus by polymerase chain reaction.通过聚合酶链反应检测爱泼斯坦-巴尔病毒。
J Clin Microbiol. 1990 Oct;28(10):2187-90. doi: 10.1128/jcm.28.10.2187-2190.1990.
6
7
8
Epstein-Barr virus DNAemia in Iranian liver transplant recipients and assessment of its variation in posttransplant lymphproliferative disorder patients by quantitative polymerase chain reaction assay.伊朗肝移植受者中的爱泼斯坦-巴尔病毒血症以及通过定量聚合酶链反应测定评估移植后淋巴增殖性疾病患者中该病毒的变异情况。
Exp Clin Transplant. 2015 Apr;13 Suppl 1:306-11. doi: 10.6002/ect.mesot2014.p148.
9
Lymphoproliferative disease of donor origin arising in patients after orthotopic liver transplantation.原位肝移植术后患者发生的供体来源的淋巴增殖性疾病。
Cancer. 1994 Nov 1;74(9):2436-41. doi: 10.1002/1097-0142(19941101)74:9<2436::aid-cncr2820740908>3.0.co;2-s.
10
Acute cellular rejection and Epstein-Barr virus-related post-transplant lymphoproliferative disorder in a pediatric lung transplant with low viral load.低病毒载量的小儿肺移植中的急性细胞排斥反应和爱泼斯坦-巴尔病毒相关的移植后淋巴组织增生性疾病
Transpl Infect Dis. 2010 Aug 1;12(4):342-6. doi: 10.1111/j.1399-3062.2009.00487.x. Epub 2009 Dec 20.
引用本文的文献
1
Limited Utility of Serology and Heterophile Test in the Early Diagnosis of Epstein-Barr Virus Mononucleosis in a Child after Renal Transplantation.血清学和嗜异性抗体检测在肾移植术后儿童传染性单核细胞增多症早期诊断中的应用价值有限。
Medicines (Basel). 2020 Apr 22;7(4):21. doi: 10.3390/medicines7040021.
2
Pediatric kidney transplantation: a historical review.小儿肾移植：历史回顾
Pediatr Res. 2017 Jan;81(1-2):259-264. doi: 10.1038/pr.2016.207. Epub 2016 Oct 12.
3
The impact of donor viral replication at transplant on recipient infections posttransplant: a prospective study.供体病毒移植时复制对移植后受体感染的影响：一项前瞻性研究。
Transplantation. 2015 Mar;99(3):602-8. doi: 10.1097/TP.0000000000000354.
4
Infectious mononucleosis hepatitis in young adults: two case reports.青年传染性单核细胞增多症性肝炎：两例报告。
Korean J Intern Med. 2009 Dec;24(4):381-7. doi: 10.3904/kjim.2009.24.4.381. Epub 2009 Nov 27.
5
Epstein-Barr virus infection in transplant recipients: Summary of a workshop on surveillance, prevention and treatment.移植受者中的爱泼斯坦-巴尔病毒感染：监测、预防和治疗研讨会综述
Can J Infect Dis. 2002 Mar;13(2):89-99. doi: 10.1155/2002/634318.
6
Donor infection: an opinion on lung donor utilization.供体感染：关于肺供体利用的观点
J Heart Lung Transplant. 2005 Jul;24(7):791-7. doi: 10.1016/j.healun.2004.05.007.
7
Two cases of post transplant lymphoproliferative disorder in lung transplant recipients.两例肺移植受者发生移植后淋巴细胞增生性疾病。
Korean J Intern Med. 2004 Dec;19(4):276-81. doi: 10.3904/kjim.2004.19.4.276.
8
The role of EBV in post-transplant malignancies: a review.EBV在移植后恶性肿瘤中的作用：综述
J Clin Pathol. 2000 Apr;53(4):248-54. doi: 10.1136/jcp.53.4.248.
9
The Epstein-Barr virus and its association with human cancers.爱泼斯坦-巴尔病毒及其与人类癌症的关联。
Mol Pathol. 1999 Dec;52(6):307-22. doi: 10.1136/mp.52.6.307.
10
Adoptive immunotherapy for Epstein-Barr virus-associated lymphoproliferative disorders complicating marrow allografts.针对异基因骨髓移植后并发的爱泼斯坦-巴尔病毒相关淋巴增殖性疾病的过继性免疫治疗。
Springer Semin Immunopathol. 1998;20(3-4):455-91. doi: 10.1007/BF00838055.
本文引用的文献
1
Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy.在环孢素-类固醇治疗下发生的淋巴瘤和淋巴增殖性病变的可逆性。
Lancet. 1984 Mar 17;1(8377):583-7. doi: 10.1016/s0140-6736(84)90994-2.
2
DNA sequence and expression of the B95-8 Epstein-Barr virus genome.B95-8型爱泼斯坦-巴尔病毒基因组的DNA序列与表达
Nature. 1984;310(5974):207-11. doi: 10.1038/310207a0.
3
Transmission of infection with herpes simplex virus by renal transplantation.
J Infect Dis. 1987 Feb;155(2):202-6. doi: 10.1093/infdis/155.2.202.
4
The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation.爱泼斯坦-巴尔病毒末端结构作为克隆性细胞增殖的标志物
Cell. 1986 Dec 26;47(6):883-9. doi: 10.1016/0092-8674(86)90803-2.
5
Long-term serological follow-up of patients for Epstein-Barr virus after recovery from infectious mononucleosis.
J Infect Dis. 1985 Jun;151(6):1150-3. doi: 10.1093/infdis/151.6.1150.
6
Epstein-Barr virus, immunodeficiency, and B cell lymphoproliferation.
Transplantation. 1985 May;39(5):461-72. doi: 10.1097/00007890-198505000-00001.
7
Infection with human immunodeficiency virus in the Pittsburgh transplant population. A study of 583 donors and 1043 recipients, 1981-1986.匹兹堡移植人群中的人类免疫缺陷病毒感染。对1981年至1986年间583名捐赠者和1043名接受者的研究。
Transplantation. 1989 Jan;47(1):134-40. doi: 10.1097/00007890-198901000-00030.
8
Genetic polymorphism of natural Epstein-Barr virus isolates from infectious mononucleosis patients and healthy carriers.传染性单核细胞增多症患者和健康携带者中自然感染的爱泼斯坦-巴尔病毒分离株的基因多态性
J Virol. 1988 Oct;62(10):3862-6. doi: 10.1128/JVI.62.10.3862-3866.1988.
9
Eradication of Epstein-Barr virus by allogeneic bone marrow transplantation: implications for sites of viral latency.异基因骨髓移植对爱泼斯坦-巴尔病毒的清除：对病毒潜伏部位的影响
Proc Natl Acad Sci U S A. 1988 Nov;85(22):8693-6. doi: 10.1073/pnas.85.22.8693.
Zotero 插件