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传染性单核细胞增多症患者和健康携带者中自然感染的爱泼斯坦-巴尔病毒分离株的基因多态性

Genetic polymorphism of natural Epstein-Barr virus isolates from infectious mononucleosis patients and healthy carriers.

作者信息

Lung M L, Chang R S, Jones J H

机构信息

Department of Microbiology, University of Hong Kong.

出版信息

J Virol. 1988 Oct;62(10):3862-6. doi: 10.1128/JVI.62.10.3862-3866.1988.

DOI:10.1128/JVI.62.10.3862-3866.1988
PMID:2901499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC253533/
Abstract

We analyzed Epstein-Barr virus (EBV) genomes from lymphoblastoid cell lines isolated from patients with infectious mononucleosis and from healthy subjects from California, Hawaii, and Hong Kong between 1970 and 1987. Using genetic polymorphism as epidemiological markers, we found that several genotypes of EBV cocirculate in a community and that although most EBV strains isolated from California and Southern China may be differentiated genotypically, there was no specific association between genotype and disease or time of isolation.

摘要

我们分析了1970年至1987年间从传染性单核细胞增多症患者以及来自加利福尼亚、夏威夷和香港的健康受试者分离出的淋巴母细胞系中的爱泼斯坦-巴尔病毒（EBV）基因组。利用基因多态性作为流行病学标记，我们发现几种EBV基因型在一个社区中共存，并且尽管从加利福尼亚和中国南方分离出的大多数EBV毒株在基因型上可能存在差异，但基因型与疾病或分离时间之间没有特定关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/8570a28fd32c/jvirol00089-0333-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/a8a024dc001d/jvirol00089-0331-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/70f05ab4a340/jvirol00089-0332-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/dc274aec9265/jvirol00089-0332-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/554240f07218/jvirol00089-0332-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/bab4b4a63299/jvirol00089-0333-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/8570a28fd32c/jvirol00089-0333-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/a8a024dc001d/jvirol00089-0331-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/70f05ab4a340/jvirol00089-0332-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/dc274aec9265/jvirol00089-0332-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/554240f07218/jvirol00089-0332-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/bab4b4a63299/jvirol00089-0333-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abad/253533/8570a28fd32c/jvirol00089-0333-b.jpg

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本文引用的文献

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Two distant regions of the Epstein-Barr virus genome with sequence homologies have the same orientation and involve small tandem repeats.爱泼斯坦-巴尔病毒基因组中两个具有序列同源性的遥远区域具有相同的方向，且涉及小串联重复序列。
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Epstein-Barr virus replication in oropharyngeal epithelial cells.爱泼斯坦-巴尔病毒在口咽上皮细胞中的复制。
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Two distant clusters of partially homologous small repeats of Epstein-Barr virus are transcribed upon induction of an abortive or lytic cycle of the virus.
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Nasal natural killer/T-cell lymphoma and its association with type "i"/XhoI loss strain Epstein-Barr virus in Chile.智利的鼻型自然杀伤/T细胞淋巴瘤及其与I型/XhoI缺失株爱泼斯坦-巴尔病毒的关联。
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Multiple Epstein-Barr virus infections in healthy individuals.健康个体中的多次爱泼斯坦-巴尔病毒感染。
J Virol. 2003 Jun;77(11):6546-50. doi: 10.1128/jvi.77.11.6546-6550.2003.
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Increased risk of malignant lymphoma indicated by elevated Epstein-Barr virus antibodies--a prospective study.爱泼斯坦-巴尔病毒抗体升高提示恶性淋巴瘤风险增加——一项前瞻性研究
Cancer Causes Control. 1993 May;4(3):187-93. doi: 10.1007/BF00051312.
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Genotypic analysis of Epstein-Barr virus associated with nasopharyngeal carcinoma of Japanese patients.与日本患者鼻咽癌相关的爱泼斯坦-巴尔病毒的基因分型分析。
Jpn J Cancer Res. 1993 Mar;84(3):246-9. doi: 10.1111/j.1349-7006.1993.tb02863.x.
在诱导爱泼斯坦-巴尔病毒的流产性或裂解性周期时，该病毒的两个远距离部分同源小重复序列簇会被转录。
J Virol. 1983 Dec;48(3):731-43. doi: 10.1128/JVI.48.3.731-743.1983.
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One of two Epstein-Barr virus nuclear antigens contains a glycine-alanine copolymer domain.两种爱泼斯坦-巴尔病毒核抗原之一含有一个甘氨酸-丙氨酸共聚结构域。
Proc Natl Acad Sci U S A. 1983 Sep;80(18):5665-9. doi: 10.1073/pnas.80.18.5665.
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Simple repeat array in Epstein-Barr virus DNA encodes part of the Epstein-Barr nuclear antigen.爱泼斯坦-巴尔病毒DNA中的简单重复序列编码爱泼斯坦-巴尔核抗原的一部分。
Science. 1983 Jun 24;220(4604):1396-8. doi: 10.1126/science.6304878.
6
Simple repeat sequence in Epstein-Barr virus DNA is transcribed in latent and productive infections.爱泼斯坦-巴尔病毒DNA中的简单重复序列在潜伏感染和增殖性感染中都会被转录。
J Virol. 1982 Oct;44(1):311-20. doi: 10.1128/JVI.44.1.311-320.1982.
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Epstein-Barr virus DNA. IX. Variation among viral DNAs from producer and nonproducer infected cells.爱泼斯坦-巴尔病毒DNA。IX。来自产生病毒的感染细胞和不产生病毒的感染细胞的病毒DNA之间的差异。
J Virol. 1981 May;38(2):632-48. doi: 10.1128/JVI.38.2.632-648.1981.
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Variations among isolates of Epstein-Barr virus.爱泼斯坦-巴尔病毒分离株之间的变异
Ann N Y Acad Sci. 1980;354:309-25. doi: 10.1111/j.1749-6632.1980.tb27974.x.
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DNA of Epstein-Barr virus VIII: B95-8, the previous prototype, is an unusual deletion derivative.爱泼斯坦-巴尔病毒VIII型的DNA：之前的原型B95-8，是一种不寻常的缺失衍生物。
Cell. 1980 Nov;22(1 Pt 1):257-67. doi: 10.1016/0092-8674(80)90173-7.
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Cyclosporin A and Epstein-Barr virus.环孢素A与爱泼斯坦-巴尔病毒
Lancet. 1980 Aug 23;2(8191):418. doi: 10.1016/s0140-6736(80)90457-2.