Yamasue K, Tochikubo O, Kono E, Maeda H
Department of Preventive Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
J Hum Hypertens. 2006 Aug;20(8):593-8. doi: 10.1038/sj.jhh.1002049. Epub 2006 May 18.
We investigated a simple device to monitor daily salt intake at home and examined the relationship between salt excretion and morning blood pressure in order to enable patients to better manage daily salt intake and hypertension. The correlation between 24-h urinary salt excretion and measured value with salt monitor from overnight urine was significant (n = 224, r = 0.72, P < 0.001). A total of 46 volunteers participated for more than 3 weeks by measuring daily salt intake and morning blood pressure. The relationship between predicted daily salt excretion and blood pressure was examined with use of 3-day moving average. Mean salt excretion and systolic blood pressure (SBP) significantly decreased by the end of the trial (i.e., salt excretion decreased from 158+/-31 to 149+/-30 mmol/day and SBP from 137+/-17 to 133+/-16 mm Hg). Of 46 participants, 18 (39%) had a significant correlation between predicted daily salt excretion and blood pressure (r > 0.4, P < 0.05, n > 21), indicating sodium sensitivity. An additional 17% had a positive correlation that did not reach statistical significance (0.2 < r < or = 0.4), and the remaining 44% had no correlation (r < or = 0.2). Mean decrease in blood pressure per decrease in salt (g) (17 mmol) intake in the 18 participants with a significant correlation was 3.3 mm Hg (SBP) and 1.5 mm Hg (diastolic blood pressure), which was higher than that reported for other studies. Hypertensive patients not using medication showed the largest decrease. We conclude that daily monitoring of salt intake and morning blood pressure will be useful for management of hypertension.
我们研究了一种在家中监测每日盐摄入量的简单装置，并检测了盐排泄量与晨起血压之间的关系，以便患者能更好地控制每日盐摄入量和高血压。24小时尿盐排泄量与过夜尿液盐监测仪测量值之间的相关性显著（n = 224，r = 0.72，P < 0.001）。共有46名志愿者通过测量每日盐摄入量和晨起血压参与研究超过3周。使用3日移动平均值检测预测的每日盐排泄量与血压之间的关系。试验结束时，平均盐排泄量和收缩压（SBP）显著降低（即盐排泄量从158±31降至149±30 mmol/天，SBP从137±17降至133±16 mmHg）。在46名参与者中，18名（39%）的预测每日盐排泄量与血压之间存在显著相关性（r > 0.4，P < 0.05，n > 21），表明存在钠敏感性。另外17%的参与者存在正相关但未达到统计学显著性（0.2 < r ≤ 0.4），其余44%的参与者无相关性（r ≤ 0.2）。在18名存在显著相关性的参与者中，盐摄入量每减少1克（17 mmol），血压平均下降幅度为3.3 mmHg（SBP）和1.5 mmHg（舒张压），高于其他研究报道。未使用药物的高血压患者血压下降幅度最大。我们得出结论，每日监测盐摄入量和晨起血压对高血压管理有用。
