Brownell B, Hughes J T
J Neurol Neurosurg Psychiatry. 1975 Apr;38(4):363-70. doi: 10.1136/jnnp.38.4.363.
The clinical features and necropsy findings are described in three cases in which severe and rapidly progressive muscle weakness developed in association with carcinoma of the bronchus. In all three cases, muscular weakness was directly responsible for death. Histological and ultramicroscopical examination in all cases showed an unusual type of degeneration of muscle fibres accompanied by degeneration of intramuscular nerve fibres, but without involvement of the central nervous system, or of the peripheral nerve trunks. The findings are compared with those of previously reported cases, and possible mechanisms for the muscle degeneration are discussed.
本文描述了3例支气管癌伴发严重且迅速进展的肌无力患者的临床特征及尸检结果。在所有3例患者中，肌无力均为直接死因。所有病例的组织学和超微结构检查均显示，肌纤维呈现一种不寻常的变性类型，伴有肌内神经纤维变性，但中枢神经系统和周围神经干未受累。将这些发现与先前报道的病例进行了比较，并讨论了肌肉变性的可能机制。
