Valente André X C N, Cusick Michael E
Biometry Research Group, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Nucleic Acids Res. 2006 May 22;34(9):2812-9. doi: 10.1093/nar/gkl325. Print 2006.
The architecture of the network of protein-protein physical interactions in Saccharomyces cerevisiae is exposed through the combination of two complementary theoretical network measures, betweenness centrality and 'Q-modularity'. The yeast interactome is characterized by well-defined topological modules connected via a small number of inter-module protein interactions. Should such topological inter-module connections turn out to constitute a form of functional coordination between the modules, we speculate that this coordination is occurring typically in a pairwise fashion, rather than by way of high-degree hub proteins responsible for coordinating multiple modules. The unique non-hub-centric hierarchical organization of the interactome is not reproduced by gene duplication-and-divergence stochastic growth models that disregard global selective pressures.
通过结合两种互补的理论网络测量方法——中介中心性和“Q-模块性”，酿酒酵母中蛋白质-蛋白质物理相互作用网络的架构得以展现。酵母相互作用组的特征是通过少量模块间蛋白质相互作用连接的定义明确的拓扑模块。如果这种拓扑模块间连接最终构成模块间功能协调的一种形式，我们推测这种协调通常以两两配对的方式发生，而不是通过负责协调多个模块的高度连接的中心蛋白。忽视全局选择压力的基因复制和分化随机增长模型无法再现相互作用组独特的非中心蛋白的层次组织。
