极地映射器：一种用于蛋白质相互作用网络和mRNA表达数据综合可视化的计算工具。
POLAR MAPPER: a computational tool for integrated visualization of protein interaction networks and mRNA expression data.
作者信息
Gonçalves Joana P, Grãos Mário, Valente André X C N
机构信息
Unidade de Sistemas Biológicos, Biocant, Cantanhede, Portugal.
出版信息
J R Soc Interface. 2009 Oct 6;6(39):881-96. doi: 10.1098/rsif.2008.0407. Epub 2008 Nov 28.
Abstract
Polar Mapper is a computational application for exposing the architecture of protein interaction networks. It facilitates the system-level analysis of mRNA expression data in the context of the underlying protein interaction network. Preliminary analysis of a human protein interaction network and comparison of the yeast oxidative stress and heat shock gene expression responses are addressed as case studies.
摘要
Polar Mapper是一款用于揭示蛋白质相互作用网络架构的计算应用程序。它有助于在潜在蛋白质相互作用网络的背景下对mRNA表达数据进行系统层面的分析。作为案例研究，文中探讨了人类蛋白质相互作用网络的初步分析以及酵母氧化应激和热休克基因表达反应的比较。
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