乳腺癌中c-erbB-2表达、S期细胞分数与预后的关系。
The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer.
作者信息
O'Reilly S M, Barnes D M, Camplejohn R S, Bartkova J, Gregory W M, Richards M A
机构信息
ICRF Clinical Oncology Unit, Guy's Hospital, London, UK.
出版信息
Br J Cancer. 1991 Mar;63(3):444-6. doi: 10.1038/bjc.1991.102.
The relationship between c-erbB-2 gene expression (assessed immunohistochemically), S-phase fraction (SPF) and prognosis has been analysed in 172 women with primary breast cancer. c-erbB-2 staining was independent of age, tumour size, number of nodes involved, tumour grade and DNA ploidy, but was more common in oestrogen receptor (ER) negative tumours (P = 0.02) and progesterone receptor (PgR) negative tumours (P = 0.03). A weak correlation between c-erbB-2 staining and SPF was observed (r = 0.18). Amongst women with node negative disease, SPF was significantly related to relapse free survival (RFS, P = 0.04) while c-erbB-2 staining was not (P = 0.2). In contrast, both SPF (P = 0.002) and c-erbB-2 staining (P = 0.016) provided significant prognostic information on RFS for women with node positive disease. Multivariate analysis showed that c-erbB-2 staining and SPF gave independent information on RFS for women with node positive disease.
对172例原发性乳腺癌女性患者分析了c-erbB-2基因表达（通过免疫组织化学评估）、S期细胞分数（SPF）与预后之间的关系。c-erbB-2染色与年龄、肿瘤大小、受累淋巴结数量、肿瘤分级及DNA倍体无关，但在雌激素受体（ER）阴性肿瘤（P = 0.02）和孕激素受体（PgR）阴性肿瘤（P = 0.03）中更常见。观察到c-erbB-2染色与SPF之间存在弱相关性（r = 0.18）。在无淋巴结转移的女性患者中，SPF与无复发生存期（RFS，P = 0.04）显著相关，而c-erbB-2染色则不然（P = 0.2）。相反，对于有淋巴结转移的女性患者，SPF（P = 0.002）和c-erbB-2染色（P = 0.016）均为RFS提供了显著的预后信息。多变量分析表明，对于有淋巴结转移的女性患者，c-erbB-2染色和SPF为RFS提供了独立的信息。
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