Nadeau J H, Herrmann B, Bucan M, Burkart D, Crosby J L, Erhart M A, Kosowsky M, Kraus J P, Michiels F, Schnattinger A
Jackson Laboratory, Bar Harbor, Maine 04609.
Genomics. 1991 Jan;9(1):78-89. doi: 10.1016/0888-7543(91)90223-2.
An interspecific backcross between lab mice and Mus spretus was used to construct a multilocus map of Chromosome 17 consisting of 12 new anonymous loci and 9 anchor loci. In addition, 7 anonymous DNA loci were added to the Chr 17 map for the BXD strains. Although we were able to identify readily the most likely gene order in the interspecific backcross, we found no evidence for an unambiguous gene order using the BXD recombinant inbred strains. Comparison of the interspecific backcross map and the BXD RI strain map revealed evidence in the interspecific backcross for a longer total genetic length, enhanced recombination distal to H-2, a segment showing suppressed recombination, and strong interference.
利用实验室小鼠与西班牙小鼠的种间回交构建了17号染色体的多位点图谱，该图谱包含12个新的匿名位点和9个锚定位点。此外，还为BXD品系在17号染色体图谱上添加了7个匿名DNA位点。尽管我们能够在种间回交中轻松确定最可能的基因顺序，但在使用BXD重组近交系时，未发现明确基因顺序的证据。种间回交图谱与BXD RI品系图谱的比较揭示，种间回交中存在总遗传长度更长、H-2远端重组增强、一段显示重组抑制以及强烈干扰的证据。
