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[出血性直肠结肠炎的治疗]

[Treatment of hemorrhagic rectocolitis].

作者信息

Modigliani R

机构信息

Service d'hépato-gastro-entérologie, hôpital Saint-Louis, Paris.

出版信息

Rev Prat. 1991 Feb 11;41(5):427-32.

PMID:1672772
Abstract

Ulcerative colitis (UC) is a chronic inflammatory disease usually localized to the mucosa of the rectum and colon. Its cause remains unknown. A few fundamental notions underlie the therapeutic approach: (1) UC generally evolves by acute episodes separated by remissions, and the therapeutic indications depend on the severity and periodicity of these acute episodes; (2) although UC is a usually benign disease it may kill in two circumstances: when a severe (or complicated) acute episode is operated belatedly, or when cancer of the colon develops; (3) the present medical treatment only has a suspensive effect on the disease; the maintenance treatment must be taken for life; (4) only total proctocolectomy can provide complete cure, and until recently this procedure required permanent ileostomy. The recently introduced ileo-anal anastomosis (after total colectomy and rectal mucosectomy) gives the same results and enable the natural anus to be spared.

摘要

溃疡性结肠炎(UC)是一种慢性炎症性疾病,通常局限于直肠和结肠的黏膜。其病因尚不清楚。治疗方法基于一些基本理念:(1)UC一般通过缓解期与急性发作交替发展,治疗指征取决于这些急性发作的严重程度和发作周期;(2)尽管UC通常是一种良性疾病,但在两种情况下可能导致死亡:严重(或复杂)急性发作时手术延迟,或发生结肠癌时;(3)目前的药物治疗仅对疾病有缓解作用;维持治疗必须终身进行;(4)只有全直肠结肠切除术才能实现完全治愈,直到最近,这种手术还需要永久性回肠造口术。最近引入的回肠肛管吻合术(全结肠切除术后和直肠黏膜切除术后)能取得相同的效果,且可保留自然肛门。

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