Sato Yasufumi
Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
Endothelium. 2006 Mar-Apr;13(2):147-55. doi: 10.1080/1062332060069110.
Angiogenesis is regulated by a local balance between the levels of endogenous stimulators and inhibitors of angiogenesis. Understanding of the mechanism of angiogenesis has advanced significantly since the discovery of two members of the family of angiogenesis stimulators, i.e., vascular endothelial growth factor family proteins and angiopoietins. These factors act on endothelial cells to stimulate angiogenesis. In contrast, most of angiogenesis inhibitors do not seem to have such characteristics. Very few genes encoding molecules that selectively inhibit angiogenesis have been discovered. This review will focus on our current understanding of endogenous inhibitors of angiogenesis.
血管生成受血管生成内源性刺激因子和抑制因子水平之间的局部平衡调节。自血管生成刺激因子家族的两个成员，即血管内皮生长因子家族蛋白和血管生成素被发现以来，对血管生成机制的理解有了显著进展。这些因子作用于内皮细胞以刺激血管生成。相比之下，大多数血管生成抑制剂似乎没有这样的特性。目前仅发现了极少数编码选择性抑制血管生成分子的基因。本综述将聚焦于我们目前对血管生成内源性抑制剂的理解。
