Baur Joseph A, Sinclair David A
Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
Nat Rev Drug Discov. 2006 Jun;5(6):493-506. doi: 10.1038/nrd2060. Epub 2006 May 26.
Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans.
白藜芦醇是红酒的一种成分，长期以来一直被怀疑具有心脏保护作用。近年来，人们对这种化合物的兴趣再度燃起，首先是因为它被鉴定为一种皮肤癌化学预防剂，随后又有报道称它能激活沉默调节蛋白去乙酰化酶并延长低等生物的寿命。尽管对其生物利用度存在怀疑，但越来越多的体内证据表明，白藜芦醇在应激和疾病的啮齿动物模型中具有保护作用。在此，我们对白藜芦醇的体内数据进行了全面而批判性的综述，并探讨了其作为人类治疗药物的潜力。
